Chronic rhinosinusitis in eosinophilic granulomatosis with polyangiitis: clinical presentation and antineutrophil cytoplasmic antibodies
ConclusionCRS in patients with EGPA is often refractory to medical and surgical management. Treatment of these patients should occur in a multidisciplinary setting.
CONCLUSION: Atopic disorders, previously recognized as predictors of poor sleep, are associated with COPCs after accounting for sleep problems. PMID: 32975542 [PubMed - as supplied by publisher]
This study analyzed cross-sectional datasets of adults (aged ≥ 40 years) in the Korean National Health and Nutrition Examination Survey 2010-2016. Health-related QoL was assessed using the 3-level EuroQoL 5-dimension component (EQ-5D-3L) index score. The presence of chronic cough and other conditions were defined using structured questionnaires. RESULTS: The prevalence of chronic cough was 3.48% ± 0.17% among adults aged ≥ 40 years. The overall EQ-5D-3L index score was significantly lower in subjects with than without chronic cough (0.79 ± 0.01 vs. 0.86 ± 0.00, P
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a prevalence of 5-10% among adults in the United States, and approximately 4% among adults in Europe.1,2 AD is associated with up-regulation of type 2 immune responses (including those involving type 2 helper T cells) and skin barrier dysfunction.3-7 Clinical characterization includes the presence of pruritus (itch) and eczematous lesions, with itching, skin pain, sleep and mental health disturbances among the most common patient complaints.
Gail initiated an enlightening string on the Wheat Belly 10-Day Grain Detox Facebook page in which she shared something she lost on the program, then something she gained while following the Wheat Belly 10-Day Grain Detox and lifestyle. Here is how it unfolded in the first few hours: “I could easily post a ‘before’ and ‘now’ picture. However, I find that most of us have so many more NSV than scale victories. “So, on that note, to encourage newbies to keep on keeping on, let’s all post at least one thing that we’ve lost and one thing that we’ve gained on this journey to ...
ConclusionAlthough the clinical benefit of omalizumab in asthma and chronic spontaneous urticaria (CSU) has been established in several clinical trials, there are very little data about its effect on severe VKC. In addition to few previously reported cases we can report the rapid effectiveness of omalizumab in VKC clinically and in terms of quality of life. Randomized trials are needed to include omalizumab in third-line treatment of VKC for prevention of visual impairment and further sequelae such as corneal damage.
Abstract Due to inconclusive findings of previous researches, we aimed to evaluate inflammatory state biomarkers in episodic and chronic migraineurs (EM and CM patients) compared to headache-free controls in the current study. Seventy-one migraine patients and 19 age-sex-matched controls were recruited. After obtaining demographic data and recording headache characteristics, blood samples were gathered and analyzed to evaluate the serum levels of C-reactive protein (CRP), tumor necrosis factor(TNF)-α and interleukin (IL)-6. Serum levels of IL-6, CRP and TNF-α were significantly higher among subjects wi...
Conditions: Asthma; Pain, Chronic; Allergy Intervention: Sponsor: Universidad de Granada Not yet recruiting
A 58-year-old woman was evaluated for persistent eosinophilia. She had joint pain with effusions for 14 years and was treated for presumptive seronegative rheumatoid arthritis with prednisone and multiple disease-modifying antirheumatic drugs with minimal improvement (timeline in Figure 1). For 2.5 years prior to evaluation, she developed a persistent pruritic rash, chronic cough, and a 20 pound weight loss. She had no atopic history and was not taking any herbal supplements. She did travel to Mexico and the US Virgin Islands within the past 2 years.
A 58-year-old woman was evaluated for persistent eosinophilia. She had joint pain with effusions for 14 years and was treated for presumptive seronegative rheumatoid arthritis with prednisone and multiple disease-modifying antirheumatic drugs with minimal improvement (Fig 1). For 2.5 years before evaluation, she had a persistent pruritic rash, chronic cough, and a 20-lb weight loss. She had no atopic history and was not taking any herbal supplements. She had traveled to Mexico and the US Virgin Islands within the past 2 years.