Molecules, Vol. 24, Pages 4397: Poly(Dopamine) Coating on 3D-Printed Poly-Lactic-Co-Glycolic Acid/ β-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

Molecules, Vol. 24, Pages 4397: Poly(Dopamine) Coating on 3D-Printed Poly-Lactic-Co-Glycolic Acid/β-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering Molecules doi: 10.3390/molecules24234397 Authors: Zhimin Xu Ningning Wang Peng Liu Yidan Sun Yumeng Wang Fan Fei Shichen Zhang Jianying Zheng Bing Han Bone defects caused by osteoporosis, bone malignant tumors, and trauma are very common, but there are many limiting factors in the clinical treatment of them. Bone tissue engineering is the most promising treatment and is considered to be the main strategy for bone defect repair. We prepared polydopamine-coated poly-(lactic-co-glycolic acid)/β-tricalcium phosphate composite scaffolds via 3D printing, and a series of characterization and biocompatibility tests were carried out. The results show that the mechanical properties and pore-related parameters of the composite scaffolds are not affected by the coatings, and the hydrophilicities of the surface are obviously improved. Scanning electron microscopy and micro-computed tomography display the nanoscale microporous structure of the bio-materials. Biological tests demonstrate that this modified surface can promote cell adhesion and proliferation and improve osteogenesis through the increase of polydopamine (PDA) concentrations. Mouse cranial defect experiments are conducted to further verify the conclusion that scaffolds with a higher content of PDA coatings have a better effect on the...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research