The potential impact of tumor suppressor genes on human gametogenesis: a case-control study

ConclusionUnexplained impaired gametogenesis in both males and females may be associated with genetic variation in TSGs. TSGs, which play cardinal roles in cell-cycle control, might also be critical for normal spermatogenesis and oogenesis. If validated in larger prospective studies, it is possible that TSGs provide an etiological basis for some patients with impaired gametogenesis.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research