A Novel Antimicrobial –Phytochemical Conjugate With Antimicrobial Activity Against Streptococcus uberis, Enterococcus faecium, and Enterococcus faecalis

In this study, we report the synthesis and antimicrobial activity of a novel sulfamethoxazole–gallic acid conjugate compound (Hybrid 1). Hybrid 1 not only showed much stronger activity than sulfamethoxazole towards Streptococcus uberis 19436, Enterococcus faecium 700221, and Enterococcus faecalis 29212, which were purchased from American Type Culture Collection (ATCC), but also exhibited a promising antimicrobial effect against two E. faecalis clinical isolates, one of which was multidrug-resistant. Further studies are warranted to establish the in vivo antimicrobial activity for Hybrid 1 and develop more potent sulfamethoxazole–gallic acid-based antimicrobial conjugates using hybrid 1 as a lead compound.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research