A Novel Antimicrobial –Phytochemical Conjugate With Antimicrobial Activity Against Streptococcus uberis, Enterococcus faecium, and Enterococcus faecalis

In this study, we report the synthesis and antimicrobial activity of a novel sulfamethoxazole–gallic acid conjugate compound (Hybrid 1). Hybrid 1 not only showed much stronger activity than sulfamethoxazole towards Streptococcus uberis 19436, Enterococcus faecium 700221, and Enterococcus faecalis 29212, which were purchased from American Type Culture Collection (ATCC), but also exhibited a promising antimicrobial effect against two E. faecalis clinical isolates, one of which was multidrug-resistant. Further studies are warranted to establish the in vivo antimicrobial activity for Hybrid 1 and develop more potent sulfamethoxazole–gallic acid-based antimicrobial conjugates using hybrid 1 as a lead compound.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionCommunity intestinal carriage of HLSR enterococci was high; however, carriage of HLGR and AR enterococci was low.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Abstract Multidrug resistance is one of the top three threats to global public health. Understanding resistance of bacteria is important to help decrease resistance and improve the development of novel antimicrobial agents or other alternative tools to combat public health challenges. Thus, the goal of this study was to investigate the vancomycin and florfenicol resistance genes of five E. faecalis and 15 E. faecium isolated from patients with urinary tract infections. There were 20 Enterococcus obtained from the library collection of randomly selected private hospitals located in the city of El Qanater El Khayrey...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Abstract Mastitis caused by multi- or pan-drug resistant bacteria is a growing health concern. A total of 110 milk samples were collected: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Enterococcus faecalis, and Escherichia coli were present in 54/110 (49.09%), 37/110 (33.63%), 25/110 (22.72%), 7/110 (6.36%), and 50/110 (45.45%) samples, respectively. A total of 20 methicillin-resistant S. aureus (MRSA) isolates, 19 Streptococcus sp. isolates, and 15 E. coli isolates were selected, and 100% were positive for (coagulase and hemolysins), streptokinase, and hemolytic activity, respectiv...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
ConclusionsEnterococcal pRE25-like elements are suspected to be widespread in MDRSP isolated from companion dogs in Korea. Considering that companion dogs live in a closely shared environment with humans, continuous surveillance of pRE25-like elements is needed for other staphylococci commonly isolated from humans.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study analyzed Escherichia coli (E. coli) and Enterococcus spp. from vegetables and soil in three urban community gardens in metro Detroit, Michigan. Bacteria were identified by PCR and 16S rRNA sequencing, followed by antimicrobial susceptibility testing, pulsed-field gel electrophoresis (PFGE), and whole-genome sequencing (WGS). E. coli was isolated from 11 of 19 (57.9%) soil samples and 23 of 48 (48%) vegetables, whereas Enterococcus spp. from 17 of 19 (89.5%) soils and 38 of 48 (79%) vegetables. The most common Enterococcus species identified in soil were Ent. mundtii (29.4%), Ent. casseliflavus (11.8%), Ent. dura...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 8 July 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Elham Jannati, Nour Amirmozaffari, Sara Saadatmand, Mohsen ArzanlouAbstractObjectivesHigh-level aminoglycoside, ampicillin and vancomycin resistance and virulence genes among enterococci isolates collected from healthy middle-school children in Ardabil, Iran, were investigated.MethodsTotally, 305 fecal specimens were collected during 2017. Isolates were subjected to antimicrobial susceptibility testing, detection of virulence genes and molecular typing.ResultsTotally, 409 isolates were collected with E. faecium as the...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
CONCLUSIONS: These findings are in line with the international literature, confirming that antimicrobial resistance is also steadily growing in Italy with rates varied for the different pathogens. PMID: 31257821 [PubMed - as supplied by publisher]
Source: Revista Espanola de Quimioterapia - Category: Drugs & Pharmacology Authors: Tags: Rev Esp Quimioter Source Type: research
Julija Armalytė1, Jūratė Skerniškytė1, Elena Bakienė1, Renatas Krasauskas1, Rita Šiugždinienė2, Violeta Kareivienė2, Sigita Kerzienė2, Irena Klimienė2, Edita Sužiedėlienė1 and Modestas Ružauskas2* 1Life Sciences Center, Institute of Biosciences, Vilnius University, Vilnius, Lithuania 2Institute of Microbiology and Virology, Lithuanian University of Health Sciences, Kaunas, Lithuania Soil is one of the biggest reservoirs of microbial diversity, yet the processes that define the community dynamics are not fully understood. Apart from soil management being vital for agricultural purposes...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion The results of our study demonstrate that robenidine is not suitable as a sole antimicrobial agent for the treatment of Gram-negative pathogen infections due to the lack of activity against the majority of Gram-negative isolates except for A. baumannii and A. calcoaceticus. However, we demonstrated in vitro efficacy against all selected Gram-negative organisms when robenidine was tested in combination with EDTA or PMBN, including against multidrug-resistant strains. Therefore, robenidine may be an appropriate candidate as a component of a combination preparation for the treatment of otitis externa in dogs. This...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion: Some Lactobacillus strains exhibit anti-CRE activity, which suggests potential applications for controlling or preventing CRE colonization or infection. Introduction Although Enterobacteriaceae are normal flora of the human intestinal system, they are also common pathogens causing human infections in the setting of both community-acquired and healthcare-associated infections (Hsueh et al., 2010; Toh et al., 2012; Lai et al., 2014; Jean et al., 2016). In this era of widespread antibiotic resistance, Enterobacteriaceae are no exception. Recently, the emergence of carbapenem-resistant Enterobacteriaceae (C...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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