Association of genes arid5b, cebpe and folate pathway with acute lymphoblastic leukemia in a population from the brazilian amazon region

Publication date: Available online 27 November 2019Source: Leukemia Research ReportsAuthor(s): Darlen Cardoso de Carvalho, Alayde Vieira Wanderley, Fernando Augusto Rodrigues Mello, André Mauricio Ribeiro dos Santos, Luciana Pereira Colares Leitão, Tatiane Piedade de Souza, Amanda de Nazaré Cohen Lima de Castro, Leandro Lopes de Magalhães, Marianne Rodrigues Fernandes, João Augusto Nunes de Carvalho, André Salim Khayat, Sidney Santos, Paulo Pimentel de Assumpção, Ney Pereira Carneiro dos SantosAbstractAcute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 genetic variants in the susceptibility of the population of the Brazilian Amazon region to B-cell ALL. The variants of the genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related to a protective effect against the development of ALL, whereas the variant of the gene ATIC was associated with a risk effect. The results suggest that genetic variants analyzed modulate of the risk of developing ALL in the studied population.
Source: Leukemia Research Reports - Category: Hematology Source Type: research