Rapid Progression to AML in a Patient with Germline GATA2 Mutation and Acquired NRAS Q61K Mutation
We present a patient with GATA2 mutation and MDS who progressed to AML over four months. Whole exome and targeted deep sequencing identified a new p.Q61K NRAS mutation in the bone marrow at the time of AML development. Rapid development of AML is possible in the setting of germline GATA2 mutation despite stable MDS, supporting close monitoring and consideration of early allogeneic transplantation. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - June 11, 2019 Category: Hematology Source Type: research

A rare case of Acute Myeloid Leukemia with der(1)t(1;19)(p13;p13.1)
We present a case of acute myeloid leukemia with der(1)t(1;19)(p13;p13.1) translocation and RUNX1 mutation. A literature review summarizing the clinical, pathological, and molecular features of the published cases is also presented. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - June 8, 2019 Category: Hematology Source Type: research

Intracranial acute promyelocytic leukemia at presentation—A case-based discussion
Publication date: 2019Source: Leukemia Research Reports, Volume 11Author(s): Kristin Sticco, Tahmeena Ahmed, Huda SalmanAbstractIntracranial disease is a very rare presentation at diagnosis in acute promyelocytic leukemia (APL). The risk associated with this particular presentation is not accounted for when the current risk stratification is based on peripheral counts. Extra medullary disease in general may challenge this risk stratification that commands initial induction treatment of this potentially fatal disease. Here we discuss a case presented at diagnosis with extensive intracranial base of the skull, clivus and sin...
Source: Leukemia Research Reports - May 29, 2019 Category: Hematology Source Type: research

Neutrophil-to-lymphocyte ratio (NLR) fails to predict outcome of diffuse large B cell lymphoma
Conclusion: Our study failed to reveal the predictive value of NLR and demonstrated that the NCCN-IPI might be the most powerful predictor in DLBCL. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 26, 2019 Category: Hematology Source Type: research

Atypical Chronic Myeloid Leukemia BCR-ABL 1 negative: A case report and literature review
Publication date: Available online 25 May 2019Source: Leukemia Research ReportsAuthor(s): Jihane Belkhair, Abderahim Raissi, Hicham Elyahyaoui, Mustapha Ait Ameur, Mohamed ChakourAbstractAtypical chronic myeloid leukemia (aCML), BCR-ABL1 negative is a rare myelodysplastic syndrome /myeloproliferative neoplasm for which no current standard of care exists. The blood smear of patients with aCML showed prominent immature granulocytosis, and granulocytic dysplasia. We admitted a 58-year-old man with splenomegaly, hyperleukocytosis, anemia, and thrombocytopenia; then cytology, cytogenetic and molecular biology analysis of bone m...
Source: Leukemia Research Reports - May 26, 2019 Category: Hematology Source Type: research

Retrospective analysis of adolescent and young adult with lymphoma at two cancer facilities in Japan
Publication date: Available online 25 May 2019Source: Leukemia Research ReportsAuthor(s): Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Ryo Saito, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Tomoki Ito, Shosaku Nomura (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - May 26, 2019 Category: Hematology Source Type: research

Tyrosine kinase inhibitor-induced carotid stenosis: a case report
Publication date: Available online 25 May 2019Source: Leukemia Research ReportsAuthor(s): Jeanne Hersant, Martine Gardembas, Georges Leftheriotis, Patrick Vandeputte, Pierre Abraham, Samir HenniAbstractTyrosine kinase inhibitors are considered as highly effective and relatively safe drugs for the treatment of chronic myeloid leukemia. If several side effects on short and long term are well known and described, their involvement in the development of carotid stenosis remains unclear. Here, we describe a case of carotid stenosis in a patient receiving tyrosine kinase inhibitors and discuss the current literature. (Source: Le...
Source: Leukemia Research Reports - May 26, 2019 Category: Hematology Source Type: research

Intracranial Acute Promyelocytic Leukemia at presentation. A Case- Based Discussion
Publication date: Available online 2 May 2019Source: Leukemia Research ReportsAuthor(s): Kristin Sticco, Tahmeena Ahmed, Huda SalmanAbstractIntracranial disease is a very rare presentation at diagnosis in acute promyelocytic leukemia (APL). The risk associated with this particular presentation is not accounted for when the current risk stratification is based on peripheral counts. Extra medullary disease in general may challenge this risk stratification that commands initial induction treatment of this potentially fatal disease. Here we discuss a case presented at diagnosis with extensive intracranial base of the skull, cl...
Source: Leukemia Research Reports - May 3, 2019 Category: Hematology Source Type: research

A Rare Case Of Near-Haploid Acute Lymphoblastic Leukemia
Publication date: Available online 22 April 2019Source: Leukemia Research ReportsAuthor(s): William Gonzalez-Marques, Ann-Leslie Zaslav, Dhana Balakrishnan, Laura Hogan, Yupo Ma, Daniel Tully, Paula Fernicola, Roxana Ponce, Htien Lee, Theresa Mercado, Tahmeena AhmedAbstractNear-haploid acute lymphoblastic leukemia is seen in 50) has a good prognosis. The correct diagnosis was critical for this patient's prognosis and treatment. The patient achieved remission after a bone marrow transplant from a 10/10 HLA matched sibling donor. He relapsed six months later and expired seven months later. This case illustrates the need for ...
Source: Leukemia Research Reports - April 23, 2019 Category: Hematology Source Type: research

Central Nervous System Post-Transplant Lymphoproliferative Disorder after Allogeneic Hematopoietic Stem Cell Transplantation: the Nagasaki Transplant Group Experience
Publication date: Available online 22 April 2019Source: Leukemia Research ReportsAuthor(s): Hikaru Sakamoto, Hidehiro Itonaga, Jun Taguchi, Takeharu Kato, Yasushi Sawayama, Tomayoshi Hayashi, Shiro Baba, Masako Moriuchi, Koichi Ohshima, Shinichiro Yoshida, Yukiyoshi Moriuchi, Yasushi MiyazakiAbstractA 17-year-old male received allogeneic transplantation for acute lymphoblastic leukemia, and presented with generalized seizures due to a solitary brain lesion with massive necrosis on day +621. Epstein-Barr virus (EBV) DNA copies were below the cut-off value in plasma. Stereotactic biopsy of the cerebral lesion confirmed the d...
Source: Leukemia Research Reports - April 23, 2019 Category: Hematology Source Type: research

Successful outcome of second allogeneic bone marrow transplantation for blastic plasmacytoid dendritic cell neoplasm with MYC locus rearrangement
Publication date: Available online 22 April 2019Source: Leukemia Research ReportsAuthor(s): Takeharu Kato, Hidehiro Itonaga, Jun Taguchi, Junya Makiyama, Machiko Fujioka, Masataka Taguchi, Makiko Horai, Yasushi Sawayama, Daisuke Niino, Yoshitaka Imaizumi, Tomoko Hata, Shinichiro Yoshida, Kana Sakamoto, Kengo Takeuchi, Koichi Ohshima, Yasushi MiyazakiAbstractA 62-year-old male was diagnosed with blastic plasmacytoid dendritic cell neoplasm (BPDCN) with a MYC rearrangement. Four months after the first unrelated bone marrow transplantation (BMT), he developed the relapsed BPDCN. After the achievement of partial remission foll...
Source: Leukemia Research Reports - April 23, 2019 Category: Hematology Source Type: research

Copy Number Aberrations in B-Cell Lymphoma: A Call for Consideration in Prognosis Determination and Therapy
Publication date: Available online 22 April 2019Source: Leukemia Research ReportsAuthor(s): Elizabeth Kertowidjojo, Kristin Sticco, Tahmeena Ahmed, Yupo Ma, Ann-Leslie Berger-Zaslav (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - April 23, 2019 Category: Hematology Source Type: research

Effective maintenance treatment with lenalidomide for a patient with aggressive adult T cell leukemia after chemotherapy
Publication date: Available online 13 April 2019Source: Leukemia Research ReportsAuthor(s): Satoko Oka, Kazuo Ono, Masaharu NohgawaAbstractAdult T cell leukemia/lymphoma (ATL) is incurable with conventional chemotherapies, and allogeneic stem cell transplantation (SCT) is the only curative treatment. Direct antitumor effects and antitumor immune responses are important factors that need to be considered in the treatment of ATL. A phase II study reported long overall survival despite short progression-free survival in patients, implying that lenalidomide confers a survival benefit through immunomodulation for patients with ...
Source: Leukemia Research Reports - April 14, 2019 Category: Hematology Source Type: research

Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia
Publication date: Available online 8 April 2019Source: Leukemia Research ReportsAuthor(s): Meiyu Chen, Jie Liu, Wei Qin, Qian Wang, Ri Zhang, Hongying ChaoAbstractThe natural history of primary hypereosinophilia remains poorly defined, given the underlying disease heterogeneity. Recently, targeted NGS helps to establish clonality in a subset of patients with hypereosinophilia. We first reported the clonal evolution in a long-term follow-up patient with hypereosinophilia. This case initially presented with chronic eosinophilic leukemia, not otherwise specified (CEL-NOS), successively transformed to myelodysplastic syndromes...
Source: Leukemia Research Reports - April 9, 2019 Category: Hematology Source Type: research

Chronic myelomonocytic leukemia as a transformation from polycythemia vera
We present a case of PV that progressed to CMML. We demonstrated the CMML clone was most likely derived from PV- JAK2V617F clone, and carried a complex genetic mutations of ASXL1, RUNX1, SRSF2 and TET2, NRAS, KRAS, plus CMML cells were of the classical phenotype CD14+ CD16− by flow cytometry. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 16, 2019 Category: Hematology Source Type: research

Matched unrelated donor hematopoietic progenitor cell transplantation: A report based on a single registry in India
ConclusionsThe patient DFS data prove that even a small registry with slightly more than 7,000 donors can yield reasonable patient outcomes. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 13, 2019 Category: Hematology Source Type: research

Myodesopsia is a symptom of central nervous system blast crisis in chronic myeloid leukemia
Publication date: Available online 5 March 2019Source: Leukemia Research ReportsAuthor(s): Kazuyoshi Ishii, Aya Nakaya, Shinya Fujita, Atsushi Satake, Yoshiko Azuma, Yukie Tsubokura, Ryo Saito, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Tomoki Ito, Shosaku NomuraAbstractA 49-year-old woman diagnosed with chronic myeloid leukemia in the chronic phase was started on dasatinib treatment, after which she complained of myodesopsia. Nineteen months after diagnosis, the patient again complained of myodesopsia and developed bilateral optic neuritis. Cerebrospinal fluid analysis revealed an increase in blasts, although periph...
Source: Leukemia Research Reports - March 6, 2019 Category: Hematology Source Type: research

Evaluation of eltrombopag in patients with aplastic anemia in real-world experience
Conclusion: Eltrombopag is a promising agent for treating patients with any degree of AA. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - March 6, 2019 Category: Hematology Source Type: research

Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
Publication date: Available online 22 November 2018Source: Leukemia Research ReportsAuthor(s): Satoko Oka, Kazuo Ono, Masaharu NohgawaAbstractThyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroi...
Source: Leukemia Research Reports - November 23, 2018 Category: Hematology Source Type: research

The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
Publication date: Available online 22 November 2018Source: Leukemia Research ReportsAuthor(s): Z. Takki Chebihi, A. Belkhayat, E. Chadli, L. Hessissen, M. El Khorassani, M. El Kababri, A. Kili, M. Khattab, Y. Bakri, N. DakkaAbstractCytogenetic studies of acute lymphoblastic leukemia have been at the forefront of research in the pathogenesis of cancer. The presence of recurring chromosomal abnormalities (either numeral or structural rearrangements) provides immediate clues to the genetic events leading to leukemia and many abnormalities have important prognostic significance. The rare translocation t(14,21)(q11.2;q22) has b...
Source: Leukemia Research Reports - November 23, 2018 Category: Hematology Source Type: research

Potentially important miRNAs in Enteropathy-Associated T-cell lymphoma Pathogenesis: a pilot study
Publication date: Available online 16 October 2018Source: Leukemia Research ReportsAuthor(s): Lindsey Clarke, Raju SR Adduri, Paul Smyth, Fiona Quinn, Michael Jeffers, Barbara Dunne, John O'Leary, Susan McKiernan, Elisabeth Vandenberghe, Saumyadipta Pyne, Murali Dharan Bashyam, Orla Sheils, Richard Flavin (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - October 16, 2018 Category: Hematology Source Type: research

High-dose Methotrexate vs. Capizzi Methotrexate for the Treatment of Childhood T-cell Acute Lymphoblastic Leukemia
Publication date: Available online 9 October 2018Source: Leukemia Research ReportsAuthor(s): Wasil JastaniahAbstractSixty-three children (1 – 14 years of age) newly diagnosed with T-cell acute lymphoblastic leukemia were treated from January 2001 to December 2014. Patient outcomes were evaluated based on the regimen received; Capizzi methotrexate (C-MTX) vs. high-dose methotrexate (HDMTX). Complete remission (CR) was achieved in 54 of 60 (90.0%) patients and 3 patients died during induction. The 5-year overall survival (OS) and disease-free survival (DFS) were 88.3±6.5% and 85±7.5%, respectively. Post-i...
Source: Leukemia Research Reports - October 9, 2018 Category: Hematology Source Type: research

Renal infiltration presenting as acute kidney injury in Hodgkin Lymphoma – a case report and review of the literature
Publication date: Available online 29 August 2018Source: Leukemia Research ReportsAuthor(s): Wellington Fernandes da Silva Junior, Laila Lopes de Farias Pinho, Cássio Lins Gil de Farias, Verônica Torres, Elerson Carlos Costalonga, George Coura Filho, Leonardo de Abreu Testagrossa, Vanderson Rocha, Valeria BuccheriAbstractRenal involvement in Hodgkin lymphoma (HL) is rare, although extralymphatic disease is usually found. Acute kidney injury is a recognized presentation of non-Hodgkin lymphoma, with bilateral kidney involvement, promptly requiring specific treatment. Regarding to HL, this manifestation is extre...
Source: Leukemia Research Reports - August 30, 2018 Category: Hematology Source Type: research

Lenalidomide induced durable remission in a patient with MDS/MPN-with ring sideroblasts and thrombocytosis with associated 5q- syndrome.
We describe a patient with MDS/MPN with ring sideroblasts and thrombocytosis who had deletions of long arm of chromosome 5 (5q-) and chromosome 20 (20q-). Molecular studies showed an exon 9, frame shift mutation in the calreticulin (CALR) gene, and absence of mutations in JAK2, MPL, SETBP1 or SF3B1.Treatment with lenalidomide resulted in durable clinical remission which has lasted 2 years. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - August 24, 2018 Category: Hematology Source Type: research

All-Trans-Retinoic-Acid and Arsenic Trioxide Induced Remission in Promyelocytic Blast Crisis
Publication date: Available online 25 July 2018Source: Leukemia Research ReportsAuthor(s): Teresa A. Colvin, Pankit Vachhani, Sheila Sait, Vishala Neppalli, Eunice S. WangAbstractA 78-year-old-male with chronic myeloid leukemia (CML) treated for seven years with dasatinib developed an acute promyelocytic leukemia complicated by disseminated intravascular coagulopathy. A promyelocytic blast crisis was diagnosed by demonstrating co-expression of chimeric BCL/ABL and PML/RARα translocations by karyotyping, fluorescence in situ hybridization, and quantitative real-time polymerase chain reaction. Promyelocytic blast crisi...
Source: Leukemia Research Reports - July 25, 2018 Category: Hematology Source Type: research

Detection of KIT mutations in Core Binding Factor acute myeloid leukemia
Publication date: Available online 21 July 2018Source: Leukemia Research ReportsAuthor(s): Passant Badr, Ghada M Elsayed, Dalia Negm Eldin, Bahia Y Riad, Hamdy NayeraAbstractWe have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (35 pediatrics and 34 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to pediatrics (22.9% and 14.7%, p=0.38) respectively. Leukocytosis ≥20 × 109 /L was significantly associated with pediatrics compared to adults. t(8;21)(q22;22) was significantly associated w...
Source: Leukemia Research Reports - July 22, 2018 Category: Hematology Source Type: research

The Role of FLT3 inhibitors as Maintenance Therapy Following Hematopoietic Stem Cell Transplant
Publication date: Available online 19 July 2018Source: Leukemia Research ReportsAuthor(s): Grace Xiuqing Li, Lan Wang, Bassam Yaghmour, Giridharan Ramsingh, George YaghmourAbstractActivating mutations in FLT3 in acute myeloid leukemia (AML) portend a poor prognosis, and targeting FLT3 with a tyrosine kinase inhibitor has been an area of intense research recently. Most FLT3 mutated AML patients undergo hematopoietic stem cell transplantation (HSCT) as standard of care but a significant proportion of patients relapse. Although the use of FLT3 inhibitors in the pre-HSCT perspective is more clearly defined, its use in the post...
Source: Leukemia Research Reports - July 20, 2018 Category: Hematology Source Type: research

Primary Isolated Bone Marrow Diffuse Large B Cell Lymphoma with Long-Term Complete Remission
Publication date: Available online 11 July 2018Source: Leukemia Research ReportsAuthor(s): Hiroko Nishida, Hiroshi Suzuki, Masao Hori, Katsuyuki ObaraAbstractSecondary bone marrow involvement of non-Hodgkin's lymphoma (NHL) is relatively common. However, primary isolated bone marrow involvement in NHL which was successfully treated and remains in complete remission (CR) for a long-term duration without any relapse is extremely rare. We herein report a patient of primary bone marrow diffuse large B cell lymphoma (PBML/DLBCL) who presented a prolonged high-grade fever and systemic purpura due to severe thrombocytopenia. The ...
Source: Leukemia Research Reports - July 12, 2018 Category: Hematology Source Type: research

Acute promyelocytic leukemia presenting with features of metastatic osseous disease
We report an unusual case of APL in a 59 year old female without peripheral blood abnormalities or diffuse marrow involvement. Clinical and radiographic findings were initially interpreted as metastatic osseous disease but ultimately found to be APL. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Tumor necrosis factor- and interleukin-6-producing high-grade B-cell lymphoma, not otherwise specified in the pleura
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Shoko Nakayama, Mitsuhiro Matsuda, Tatsuya Adachi, Sanae Sueda, Kayo Ueda, Kunimitsu Kawahara, Yuka Ohashi, Sumie Awaji, Shigeo Hashimoto, Itaru MatsumuraAbstractA 65-year-old man was admitted to our hospital with left-sided chest and back pain and dyspnea. Computed tomography demonstrated a marked circumferential left pleural thickening. A thoracoscopic pleural biopsy led to a diagnosis of high-grade B-cell lymphoma, not otherwise specified (HGBL, NOS). Lymphoma cells were positive for tumor necrosis factor (TNF) and interleukin-6. This is the fi...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Retrospective analysis of primary plasma cell leukemia in Kansai Myeloma Forum registry
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Aya Nakaya, Hideo Yagi, Hitomi Kaneko, Satoru Kosugi, Toru Kida, Yoko Adachi, Hirohiko Shibayama, Takae Kohara, Yuri Kamitsuji, Shin-ichi Fuchida, Nobuhiko Uoshima, Eri Kawata, Hitoji Uchiyama, Yuji Shimura, Takayuki Takahashi, Fumiaki Urase, Kensuke Ohta, Tsuneyoshi Hamada, Kazue Miyamoto, Masayuki KobayashiAbstractWe retrospectively analyzed twenty-six patients with primary plasma cell leukemia (pPCL) registered from May 2005 until April 2015 by the Kansai Myeloma Forum. Twenty patients received novel agents (bortezomib or lenalidomide), and the...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Case report: Exome sequencing identifies T-ALL with myeloid features as a IKZF1-struck early precursor T-cell malignancy
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Marcus C. Hansen, Line Nederby, Eigil Kjeldsen, Marianne A. Petersen, Hans B. Ommen, Peter Hokland (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Alemtuzumab-based therapy for Secondary Malignant Histiocytosis arising from Pre-B-ALL
This report is the first to highlight the role of alemtuzumab, an anti-CD52 monoclonal antibody, in clonal disorders originating from transdifferentiation.•The alemtuzumab-based regimen should be reserved only for carefully selected allogeneic transplant patients. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Expression of a specific extracellular matrix signature is a favorable prognostic factor in acute myeloid leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Valerio Izzi, Juho Lakkala, Raman Devarajan, Eeva-Riitta Savolainen, Pirjo Koistinen, Ritva Heljasvaara, Taina PihlajaniemiAbstractRelapse of acute myeloid leukemia (AML) is still dramatically frequent, imposing the need for early markers to quantify such risk. Recent evidence point to a prominent role for extracellular matrix (ECM) in AML, but its prognostic value has not yet been investigated. Here we have investigated whether the expression of a 15-ECM gene signature could be applied to clinical AML research evaluating a retrospective cohort of ...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Essential thrombocytemia following immune thrombocytopenia with JAK2V617F mutation
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Giovanni Caocci, Sandra Atzeni, Monica Usai, Giorgio La NasaAbstractJAK2V617F mutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only 2 reports described ET following ITP. For the first time we analyzed in a patient the JAK2V617F allele burden at ITP onset occurred 13 years before the ET diagnosis and found the presence of a small clone JAK2V617F positive clone (3%) raised to 27% in the...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Subcutaneous rituximab given to patients for other indications than CD20+ B-cell lymphoma: A monocentric study of 20 cases
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Pierre Peterlin, Thierry Guillaume, Alice Garnier, Amandine Le Bourgeois, Beatrice Mahé, Viviane Dubruille, Nicolas Blin, Pierre Gallas, Cyrille Touzeau, Thomas Gastinne, Anne Lok, Patrick Thomare, Cecile Chauvin, Steven Le Gouill, Philippe Moreau, Patrice Chevallier (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Unrelated HLA mismatched microtransplantation in a patient with refractory secondary acute myeloid leukemia
We describe the first reported patient with refractory AML who underwent salvage MST from an unrelated, complete HLA-mismatched donor. The patient achieved remission without complication, warranting further study of unrelated HLA-mismatched donor MST in AML. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Rituximab monotherapy become an optimal treatment for primary pulmonary malt lymphoma
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): A.I. Alvarez-Sánchez, C. Martínez-Losada (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

A rare case of a minimally secretory plasma cell leukemia with a hemorrhagic gastric plasmacytoma
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Akshjot Puri, Michelle W. Lau, Xianfeng F. Zhao, Keith C. Chan, Kimberly Bader (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Forskolin attenuates doxorubicin-induced accumulation of asymmetric dimethylarginine and s-adenosylhomocysteine via methyltransferase activity in leukemic monocytes
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Sandhiya Ramachandran, Swetha Loganathan, Vinnie Cheeran, Soniya Charles, Ganesh Munuswamy-Ramanujan, Mohankumar Ramasamy, Vijay Raj, Kanchana MalaAbstractDoxorubicin (DOX) is an antitumor drug, associated with cardiomyopathy. Strategies to address DOX-cardiomyopathy are scarce. Here, we identify the effect of forskolin (FSK) on DOX-induced-asymmetric-dimethylarginine (ADMA) accumulation in monocytoid cells. DOX-challenge led to i) augmented cytotoxicity, reactive-oxygen-species (ROS) production and methyltransferase-enzyme-activity identified as A...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Secondary pure red cell aplasia in multiple myeloma treated with lenalidomide
Publication date: 2018Source: Leukemia Research Reports, Volume 10Author(s): Tomoki Ito, Aya Nakaya, Shinya Fujita, Atsushi Satake, Takahisa Nakanishi, Yoshiko Azuma, Yukie Tsubokura, Akiko Konishi, Masaaki Hotta, Hideaki Yoshimura, Kazuyoshi Ishii, Shosaku NomuraAbstractPure red cell aplasia (PRCA) is a rare disorder characterized by marked erythroid hypoplasia with maturation arrest in the bone marrow. Secondary acquired PRCA may be associated with hematologic disorders. A few case reports have described PRCA associated with multiple myeloma (MM). However, the clinical course and mechanism of PRCA associated with MM rema...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

1,25-OH2 vitamin D3 and AKT-inhibition increase glucocorticoid induced apoptosis in a model of T-cell acute lymphoblastic leukemia (ALL)
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Maximilian Pistor, Lisa Schrewe, Steffen Haupeltshofer, Andrei Miclea, Simon Faissner, Andrew Chan, Robert HoepnerAbstractIn acute lymphoblastic leukemia (ALL), steroid resistance and hypovitaminosis D are both associated with a poor prognosis. We show that methylprednisolone, calcitriol and the AKT-inhibitor MK-2206 have a synergistic effect on the apoptosis of steroid resistant T-ALL cells. Compared to methylprednisolone monotherapy, calcitriol increases methylprednisolone induced apoptosis dose-dependently (1.37–1.92-fold; p 
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Anti-CD19 chimeric antigen receptor targeting of CD19 + acute myeloid leukemia
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Gina Ma, Yi Wang, Tahmeena Ahmed, Ann-Leslie Zaslav, Laura Hogan, Cecilia Avila, Masayuki Wada, Huda SalmanAbstractAberrant expression of CD19 in acute myeloid leukemia (AML) is commonly associated with t(8;21)(q22;q22), although AML cases lacking this translocation occasionally express CD19. Mixed-phenotype acute leukemia also frequently expresses CD19. Chimeric antigen receptor (CAR) technology is a major breakthrough for cancer treatment, with the recent approval of CD19-directed CAR (CD19CAR) for treating B-cell malignancies. However, little in...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

A case of chronic eosinophilic leukemia with secondary transformation to acute myeloid leukemia
We describe a case of CEL-NOS with two hierarchically related non-specific cytogenetic rearrangements, associated with an NPM1 mutation and followed by evolution to secondary AML. NPM1 mutations are not previously described in CEL-NOS. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

The fear of lymphadenopathy: A cautionary case of sarcoidosis masquerading as recurrent diffuse large b-cell lymphoma (DLBCL)
We describe the cautionary case of a patient with advanced-stage large B-cell lymphoma (DLBCL). After combination chemotherapy, CT-PET revealed a persistent focus of likely DLBCL for which he received radiotherapy. Follow-up CT-PET showed diffuse hypermetabolic adenopathy and recurrent DLBCL was presumed. As part of clinical trial assessment, multiple biopsies showed non-caseating lymphadenitis consistent with sarcoidosis. No treatment for asymptomatic sarcoidosis was required and 18 months later he remains cancer-free. The presentation of sarcoidosis masquerading as recurrent DLBCL highlights the importance of tissue samp...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Delayed diagnosis of Shwachman diamond syndrome with short telomeres and a review of cases in Asia
We report a case of delayed diagnosis of SDS in a family with another child with aplastic anemia, and review reported cases of SDS in Asia. This highlights the gap in identifying inherited bone marrow failure syndromes in adults with hematologic malignancies. (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Systemic lupus erythematosus and myelofibrosis: A case report and revision of literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): F. Del Porto, C. Tatarelli, A. Di Napoli, M. ProiettaAbstractBlood cytopenia represents one of the diagnostic criteria for systemic lupus erythematosus (SLE) and may occur as the first symptom of the disease. Antibody-mediated peripheral destruction of blood cells is the main cause of cytopenia observed in patients affected by SLE, however, inflammatory anemia, nutritional deficiencies, immunosuppressive therapy and, more rarely, myelofibrosis (MF) have also been documented. In the literature, 45 cases of autoimmune MF (AIMF) and SLE have been prev...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Daria Gaut, Joshua Sasine, Gary SchillerAbstractAlthough rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy of chromosome 7, and ...
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Sezary syndrome manifesting as posttransplant lymphoproliferative disorder
We present a patient with myelodysplastic syndrome (MDS) post matched unrelated donor alloHSCT who was on long-term immunosuppressive therapy due to graft versus host disease. Three years after an alloHSCT, she developed generalized erythroderma and peripheral blood lymphocytosis. Both skin biopsy and peripheral blood flow cytometry revealed atypical CD4+ T-cell population consistent with diagnosis of Sezary syndrome. Chimerism studies revealed 100% donor engraftment. Therapy with extracorporeal photopheresis resulted in complete response in blood and skin.Graphical abstract (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research

Acute myeloid leukemia with t(4;12)(q12;p13) treated with an allogeneic stem cell transplant: A case report and review of the literature
Publication date: 2018Source: Leukemia Research Reports, Volume 9Author(s): Christie Hancock, Dimitra Kanaloupitis, Ronald Sirota, Jillene Kogan, Leonard Klein, John Eklund (Source: Leukemia Research Reports)
Source: Leukemia Research Reports - July 10, 2018 Category: Hematology Source Type: research