Dental mesenchymal stem cells and neuro-regeneration: a focus on spinal cord injury

AbstractRegenerative medicine is a branch of translational research that aims to reestablish irreparably damaged tissues and organs by stimulating the body ’s own repair mechanismsvia the implantation of stem cells differentiated into specialized cell types. A rich source of adult stem cells is located inside the tooth and is represented by human dental pulp stem cells, or hDPSCs. These cells are characterized by a high proliferative rate, have self-renewal and multi-lineage differentiation properties and are often used for tissue engineering and regenerative medicine. The present review will provide an overview of hDPSCs and related features with a special focus on their potential applications in regenerative medicine of the nervous system, such as, for example, after spinal cord injury. Recent advances in the identification and characterization of dental stem cells and in dental tissue engineering strategies suggest that bioengineering approaches may successfully be used to regenerate districts of the central nervous system, previously considered irreparable.
Source: Cell and Tissue Research - Category: Cytology Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study verifies that co-delivery of VEGF/NT-3 reduces inflammation and gliosis in the hemisected spinal cord, promotes axonal outgrowth and results in better locomotor recovery, while the BMSCs transplantation facilitates these functions limitedly. PMID: 31899965 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
This article aimed to investigate effects of exosomes secreted from miRNA-29b-modified bone marrow mesenchymal stem cells (BMSCs) on SCI. Exosomes were extracted from BMSCs transfected with miRNA-29b or negative control (miR NC). SCI rats were injected intravenously with exosomes (control exosomes, miRNA-29b exosomes) and BMSCs (miR NC, miRNA-29b) through the tail vein. The expression of miRNA-29b in spinal cord tissues of SCI rats was detected by qRT-PCR. The hind limb motor function was evaluated by Basso Beattie Bresnahan (BBB) score. The histopathological damage and neuronal regeneration in spinal cord tissues was obse...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
Response of spinal cord ependymal stem cells to spinal cord injury. A, Glutamate stimulates neural stem/progenitor cell (NSPC) proliferation and enhances survival through AMPA receptor activation. B, M1 macrophages increase pro ‐inflammatory cytokine mRNA expression in NSPCs and enhance proliferation through MAPK‐Sox2 signaling. M2 macrophages increase anti‐inflammatory cytokine mRNA expression in NSPCs, reduce proliferation, and increase neuronal differentiation. C, Myelin‐derived inhibitory proteins limit NSPC pr oliferation and neuronal differentiation via NgR1 signaling. D, NSPCs maintain a high endogenous leve...
Source: Stem Cells - Category: Stem Cells Authors: Tags: TISSUE ‐SPECIFIC STEM CELLS Source Type: research
In this study, tissue-engineered nerves were first constructed by adipose-derived Schwann-like cells and ANAs to bridge missing sciatic nerves. Then, the rats were randomly divided into five groups (n=12 per group): a Control group; a Model group; an ADSC group; an SC-L group; and a DMEM group. Twelve weeks postsurgery, behavioral function tests and molecular biological techniques were used to evaluate the function of regenerated nerves and the relevant molecular mechanisms after sciatic nerve injury (SNI). The results showed that adipose-derived Schwann-like cells combined with ANAs markedly promoted sciatic nerve regener...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 23 October 2019Source: Materials Science and Engineering: CAuthor(s): Maxime Bonnet, Thomas Trimaille, Brezun Jean-Michel, François Feron, Didier Gigmes, Tanguy Marqueste, Patrick DecherchiAbstractIn line with experiments showing that implanted hydrogels are promising tools, we designed and injected, after a C2 spinal cord hemisection, a thermoresponsive and thermoreversible physically cross-linked poly(N-isopropylacrylamide)-poly(ethylene glycol) copolymer in order to reduce functional deficits and provide a favorable environment to axotomized axons.Nasal olfactory ecto-mesenchyma...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Response of spinal cord ependymal stem cells to spinal cord injury. A, Glutamate stimulates neural stem/progenitor cell (NSPC) proliferation and enhances survival through AMPA receptor activation. B, M1 macrophages increase pro ‐inflammatory cytokine mRNA expression in NSPCs and enhance proliferation through MAPK‐Sox2 signaling. M2 macrophages increase anti‐inflammatory cytokine mRNA expression in NSPCs, reduce proliferation, and increase neuronal differentiation. C, Myelin‐derived inhibitory proteins limit NSPC pr oliferation and neuronal differentiation via NgR1 signaling. D, NSPCs maintain a high endogenous leve...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research
Mind-reading exoskeletons, digital tattoos, 3D printed drugs, RFID implants for recreational purposes: mindblowing innovations come to medicine and healthcare almost every single day. We shortlisted some of the greatest ideas and developments that could give us a glimpse into the future of medicine, but we found so many that we had trouble fitting them into one article. Here are the first ten spectacular medical innovations to watch for. 1) Mixed reality opens new ways for medical education Augmented, virtual, and mixed reality are all technologies opening new worlds for the human senses. While the difference between...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing artificial food brain-computer interface cyborg digital tattoos drug development exoskeleton gamification google glass health insurance Healthcare Innovation List Medical education medical techn Source Type: blogs
Proposed model depicting the epidermal growth factor receptor ‐extracellular‐regulated kinase‐TRIM32 signaling axis in the regulation of neuronal differentiation. A, Under myelin‐associated inhibition, protein kinase C‐, Src‐Pyk2‐induced epidermal growth factor receptor‐extracellular‐regulated kinase signaling pathway was activated, resulting in TRIM32 inhibition and neuronal differentiation of neural stem cells inhibition. B, Cetuximab and gefitinib can directly block epidermal growth factor receptor. Go6976 and PP2 were used to inhibit PKC and Src‐Pyk2, respectively, which resulted in epidermal growth...
Source: Stem Cells - Category: Stem Cells Authors: Tags: TISSUE ‐SPECIFIC STEM CELLS Source Type: research
In this study, we further explored the mechanisms by which NSC-sEVs repair spinal cord injury via autophagy. We found that NSC-sEVs contain 14-3-3t protein, of which the overexpression or knockdown enhanced and decreased autophagy, respectively. In addition, 14-3-3t overexpression enhanced the anti-apoptotic and anti-inflammatory effects of NSC-sEVs, further promoting functional behavior recovery following spinal cord injury. The overexpression of 14-3-3t was used to further validate the in vivo results through a series of in vitro experiments. Conversely, knockdown of 14-3-3t attenuated the anti-apoptotic and anti-inflamm...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
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