Antibiotic prophylaxis in vaccinated eculizumab recipients who developed meningococcal disease

We recently published a case series of typically commensal Neisseria spp. disease among eculizumab recipients.1 Eculizumab is a terminal complement inhibitor indicated for treatment of paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and certain patients with generalized myasthenia gravis or neuromyelitis optica spectrum disorder.2 Due to complement inhibition, many different Neisseria spp. can cause invasive disease in eculizumab recipients1, 3, 4 and eculizumab recipients are at an estimated 2000-fold increased risk of meningococcal disease (caused by Neisseria meningitidis).
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research

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CONCLUSION: We report a case of chronic enterovirus infection associating meningitis and myofasciitis in an adult with rituximab-induced hypogammaglobulinemia. Outcome was favorable under treatment with intravenous immunoglobulins. PMID: 31980187 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Publication date: Available online 26 January 2020Source: Food ControlAuthor(s): Hanxu Pan, Kai Dong, Lei Rao, Liang Zhao, Xiaomeng Wu, Yongtao Wang, Xiaojun LiaoAbstractEscherichia coli O157:H7, the causative agent of haemorrhagic colitis and haemolytic uremic syndrome in humans, has been implicated in large food-borne outbreaks all over the world. When confronted with harsh environmental stresses, it can enter into a viable but nonculturable (VBNC) state, which poses a great risk to food safety and public health since conventional methods are invalid to detect VBNC cells. Herein, a system for detecting VBNC state Escheri...
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 25 January 2020Source: Veterinary MicrobiologyAuthor(s): Mar Costa-Hurtado, Emili Barba-Vidal, Jaime Maldonado, Virginia AragonAbstractAntimicrobials have been commonly used to control bacterial diseases in farm animals. The efficacy of these drugs deterred the development of other control measures, such as vaccines, which are currently getting more attention due to the increased concern about antimicrobial resistance. Glässer’s disease is caused by Glaesserella (Haemophilus) parasuis and affects pork production around the world. Balance between colonization and immunity seems ...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 25 January 2020Source: Preventive Veterinary MedicineAuthor(s): Andnet Yirga, Wudu T. Jemberu, Nicholas Lyons, Alemseged Gebru, Fasil Akililu, Jonathan Rushton
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Authors: Haese N, Powers J, Streblow DN Abstract Chikungunya virus (CHIKV) infection in humans is rarely fatal but is often associated with chronic joint and muscle pain. Chronic CHIKV disease is highly debilitating and is associated with viral persistence. To date, there are no approved vaccines or therapeutics to prevent or treat CHIKV infections once they are established. Current palliative treatments aim to reduce joint inflammation and pain associated with acute and chronic CHIKV disease. Development of novel therapeutics that reduces viral loads should positively impact virus inflammatory disease and improve ...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler Guest: Ralph Baric Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV 2020 WHO coronavirus sitreps CIDRAP article on coronavirus vaccines Phylogenetic analysis of 2019-nCoV ACE2 is 2019-nCoV receptor (bioRxiv) Visual explainer of Huanan market (SCMP) Clinical features of 2019-nCoV patients (Lancet...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Source: Global Public Health - Category: International Medicine & Public Health Authors: Source Type: research
(CNN) — What started as a mystery virus last month in Wuhan, China, has now killed more than two dozen people and infected hundreds more around the world. In the U.S., the first cases of Wuhan coronavirus were confirmed this week — a man in his 30s who is under observation in Washington state and a Chicago woman in her 60s — stoking fears of an outbreak in this country, though health officials say the risk for Massachusetts residents getting the virus is low. So what are officials doing in the U.S., and how can you minimize your risk? What airports are doing Passengers from Wuhan to the United States &mda...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Coronavirus Source Type: news
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