Protective effect of Lithium Chloride against Trimethyltin-induced hippocampal degeneration and comorbid depression in rats

Abstract Pathophysiology of depression is a controversial issue. The present study aimed at investigating the pathophysiology of depression in trimethyltin (TMT) intoxication as a hippocampal degeneration inducer. The effect of Lithium Chloride (LiCl) chronic administration on the amelioration of depression symptoms was also investigated. The rats were injected with single dose of TMT (8 mg/kg intra-peritoneal). The three test groups received 20, 40 and 80 mg/kg of LiCl respectively. Likewise, the vehicle treated group received saline for fourteen day. In order to assess the depression level, the immobility time of the rats was measured in the forced swim test (FST) and tail suspension test (TST). Then, the serum levels of tumor necrotic factor alpha (TNF-α) and brain derived neurotrophic factor (BDNF) were measured. Histological methods were then used to determine degenerated neurons and cell density in the hippocampus. An increase in the immobility time in FST and TST was seen in the rats who received TMT, while the rats receiving LiCl showed a significantly decreased immobility. In addition, LiCl administration increased the serum level of BDNF, while it decreased the serum level of TNF –α after TMT intoxication. The number of degenerated neurons in CA1, CA2, CA3 and DG of LiCl-treated groups were lower than that of vehicle treated group. LiCl treatment increased hippocampal cell density, especially in CA3 subfield. Taken together, the ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Some of the most common symptoms experienced by cancer patients are memory problems, difficulties with multitasking, and reduced attention and concentration. Historically, cancer patients with these symptoms were often diagnosed with depression. Research over the past decade has revealed that many cancer patients experience such symptoms as a consequence of specific damage to the brain caused by either their tumor or their treatment. While radiation to the brain has long been linked to causing cognitive difficulties, the effects of chemotherapy on brain structure and function have only recently been discovered. We now know...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Cancer Memory Radiation Source Type: blogs
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease Source Type: news
Authors: Ferreira LP, Pinheiro CF, Fernandes NA, Ferreira CN PMID: 31730304 [PubMed - in process]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Say the word. Suicide. Say it aloud. Say it more than once. Say it until it sounds like any other word.  Our minds give words power, connotations, and destructive or healing qualities. Words, alone, can attack the body with symptoms of fear and uncertainty and, at the same time, be inexact and open to interpretation. What if you could rob a word like “suicide” of some of its isolating effect and control?  Words are serious business. What they represent – true or not – are real problems that need real solutions. Taking control of the power of words is one strategy that places the focus wher...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Stigma Suicide crisis Power of words Semantics Source Type: blogs
In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health. Towards a Rigorous Definition of Cellular Senescence https://www.fightaging.org/archives/2019/11/towards-a-rigorous-definition-of-cellular-senescence/ The accumulation of lingering senescent cells is a significant cause of aging, disrupting tissue function and generating chronic inflammation throughout the body. Even while the first senolytic drugs capable of selectively destroying these cells already exist, and while a number of biotech companies are working on the productio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study analyzes the tumor homing and therapeutic abilities of clinical grade human mesenchymal stem cells (MSCs) in an orthotopic glioblastoma mouse model. Our time course analysis demonstrated that MSCs display a rapid targeted migration to intracerebral U87 glioma xenografts growing in the contralateral hemisphere within the first 48h hours after application as assessed by histology and 7T magnetic resonance imaging. MSCs accumulated predominantly peritumorally but also infiltrated the main tumor mass and targeted distant tumor satellites while no MSCs were found in other regions of the brain. Intratumoral applicatio...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
One major reason Americans don’t get enough exercise is they feel they don’t have enough time. It can be difficult to squeeze in the 75 minutes of vigorous aerobic exercise per week that federal guidelines recommend; only about half of Americans do, according to the most recent numbers from the Centers for Disease Control and Prevention. But new research suggests people may be able to get life-lengthening benefits by running for far less time. In a new analysis of 14 studies, researchers tracked deaths among more than 232,000 people from the U.S., Denmark, the U.K. and China over at least five years, and compar...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Exercise/Fitness Source Type: news
In this study, we sought to investigate behavioral and molecular response patterns at mid-adulthood linked to early-life immune activation. Using affective behavioral test batteries, we showed that lipopolysaccharide (LPS)-induced postnatal immune challenge caused anxiety-like behaviors in both male and female Wistar rats at mid-adulthood, whereas only female rats exhibited depression-like behaviors. Our data further demonstrated a significant increase in microglial complexity and increased levels of tumor necrosis factor (TNFα), nitric oxide (NOx), and lipid peroxidation in the prefrontal cortex of female rats compa...
Source: Neuroscience - Category: Neuroscience Source Type: research
Each Halloween we encounter the same debate: are haunted asylums stigmatizing or are they simply entertainment? While some may think haunted asylums are tasteless at worst, they don’t feel like they’re an actual detriment to the mental illness community. In this episode, we look at this argument from both sides and really dig into what happens when we use mental illness as a theme for entertainment.  While Jackie and Gabe both make great arguments, we toss this question back to you.  Are you offended by haunted asylums or do you see them as harmless entertainment — or something in between? Liste...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Stigma Trauma Source Type: blogs
CONCLUSION: This research suggested that the MSCTK/GCV system exerts a strong bystander effect on GBM tumor cells, and this system may be a promising assistant method for GBM postoperative therapy. PMID: 31657679 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research
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