Selective media and real-time PCR improves diagnosis of melioidosis in community-acquired pneumonia in a low-incidence setting in Kuala Lumpur, Malaysia.

Conclusions. In a low-incidence setting, selective culture of respiratory samples on Ashdown was more sensitive and allowed quicker identification than routine media, at reasonable cost. Blood cultures are critical, confirming four cases missed by routine respiratory culture. Selective medium is useful in early pneumonia (pre-sepsis) and resource-limited settings where blood cultures are infrequently done. Real-time PCR is costly, but highly sensitive and useful for high-risk patients with diabetes, cancer or immunosuppressants, or requiring ventilation or intensive care. PMID: 31750812 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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Source: Pediatric Hematology and Oncology - Category: Pediatrics Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Journal of OrthopaedicsAuthor(s): Alex Gu, Frank R. Chen, Aaron Z. Chen, Safa C. Fassihi, Savyasachi Thakkar, Anthony S. Unger, Jiabin Liu, Peter K. Sculco, P. MichaelAbstractIntroductionThe purpose of this study is to investigate the relationship between preoperative hyponatremia and postoperative complications in aseptic revision hip and knee arthroplasty.MethodsAseptic revision arthroplasties from 2007-2016 were collected using a large, United States database. Patients were stratified into eunatremic and hyponatremic cohorts. Rates of complications were collected...
Source: Journal of Orthopaedics - Category: Orthopaedics Source Type: research
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Source: Ophthalmic Epidemiology - Category: Opthalmology Authors: Source Type: research
This study aimed to offer a reference for the rational indications of AT.Methods: We retrospectively included 1216 stage IB GC who experienced curative surgery from the SEER database between 2004 and 2015. These patients were allocated into two groups: Group AT and Group surgery alone (Group SA). We established a nomogram to predict OS and then divided whole cohort into low-risk and high-risk groups based on the OS predicted by the nomogram.Results: Six variables, which were significantly related with OS of entire patients after matched, were incorporated in the nomogram. These variables were age, examined lymph nodes, tum...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
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Source: Endocrine Research - Category: Endocrinology Authors: Source Type: research
In this study, we demonstrate the use of lipids as co-surfactants for the preparation of mixed micelles to improve the siRNA delivery of cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were polymerized on the surface of cholic acid to afford a star-shaped block copolymer with four arms (CA-PAGE-b-PEG)4. The allyl groups of PAGE were functionalized to bear primary or tertiary amines and folic acid was grafted onto the PEG chain end to increase cell uptake. (CA-PAGE-b-PEG)4 functionalized with either primary or tertiary amines show high siRNA complexation with close to 10...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 January 2020Source: International Journal of PharmaceuticsAuthor(s): Kharkar Prachi Balaram, Talkar Swapnil Sunil, Patravale Vandana BharatAbstractThe aim of this study is to formulate thermodynamically stable docetaxel loaded nanostructured lipid carriers (DTX-NLCs) for parenteral cancer therapy with improved long term stability and better pharmacokinetic performance. DTX-NLCswere formulated using microemulsion(ME) template technique and characterized for particle size,entrapment efficiency (EE%), drug content and in vitro release kinetics. Further evaluation of NLCs was carried out b...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Psychosocial Oncology - Category: Cancer & Oncology Authors: Source Type: research
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