Splenic Rupture Secondary to Vascular Ehlers –Danlos Syndrome Managed by Coil Embolization of the Splenic Artery

Conclusions There are only four reports of V-EDS causing splenic rupture in the literature to date. These patients were all adults and only one had not previously been diagnosed with V-EDS. All underwent splenectomy. While V-EDS presenting with abdominal visceral rupture in children has been reported, this is the first report of a child with V-EDS presenting with splenic rupture. It is the only case of splenic rupture secondary to V-EDS that has been managed minimally invasively by embolization. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: European Journal of Pediatric Surgery Reports - Category: Surgery Authors: Tags: Review Article Source Type: research

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Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Authors: Ertel KA, Hallam JE, Hillman AR Abstract BACKGROUND: Individuals participating in exercise beyond their level of fitness may be at higher risk for exercise-induced muscle damage, however the impact of training status on muscle damage development is not well understood. The purpose of this study was to measure skeletal muscle damage and soreness after five days of high and low intensity exercise in previously trained and untrained individuals. METHODS: Eighteen males and females (9 trained and 9 untrained) completed five consecutive days of high intensity (HI) exercise and five consecutive days of low i...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
Heparin has a non-predictable effect in the individual patient. The activated clotting time (ACT) is used to measure the level of anticoagulation after administration of heparin. To date, appropriate heparin dose protocols and corresponding therapeutic ACT values have not been established in non-cardiac arterial procedures (NCAP). The aim of this review was to study the use of ACT monitoring during NCAP, and whether an optimal ACT could be determined based on the fewest arterial thrombo-embolic complications (ATEC) and bleeding complications.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
I haven't used Stimwave since fellowship. Anyone using their technology for peripheral nerve stim? Results? Pros/Cons and feedback from patients? If I were going to use it, it would probably be for suprascapular neuralgia, genicular nerualgia, and/or SI joint pain vs cluneal neuralgia, when other options have failed (i.e. RF).
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
How bad of an idea is it to be pregnant with adequate lead coverage during early months of pregnancy? I had a fellow resident who was pregnant who changed her rotations around to avoid any exposure, however it's my understanding that overall the exposure with adequate coverage is ultimately fine. I know most of you are men - not sure if there are any female pain docs who could chime in? Sigh.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Dear Dr. Ducttape, Beginning in 2020, our Board will offer its longitudinal assessment technology to diplomates of other medical specialties to maintain their Pain Medicine certification. Until now, diplomates of our co-sponsoring boards – American Boards of Physical Medicine and Rehabilitation (ABPMR), Psychiatry and Neurology (ABPN), and Radiology (ABR) – with current certificates in Pain Medicine took a high-stakes recertification exam every 10 years. Our Pain Medicine-certified... New for Pain Recertification- re PMR
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
(Houston Methodist) Surgeons at Houston Methodist Hospital are stemming the tide of addiction to prescription opioids by managing patients' pain after surgery.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Columbia University Irving Medical Center) A new study from researchers at Columbia University Vagelos College of Physicians and Surgeons found that non-medical cannabis use -- including frequent or problematic use -- is significantly more common in adults with pain than in those without pain.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This article reviews results from preclinical and healthy volunteer studies that illustrate the noteworthy properties of apixaban such as a proportional dose-response relationship, low daily fluctuation in plasma concentrations, and safety over a 10-fold dosing range. Additionally, the large phase III trials evaluating the safety and efficacy of apixaban compared to low molecular weight heparin (LMWH) overlapped with and followed by vitamin K antagonist (VKA) warfarin for the treatment and secondary prevention of VTE will be discussed. The key studies that have led to apixaban's current licensing and use will be highlighte...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Brearton C, Rushton A, Parker J, Martin H, Hodgson J Abstract Viscoelastic Coagulation Testing (VCT), or Thromboelastography has the potential to improve the cost and clinical effectiveness of surgical and medical care by preventing unnecessary treatment and by improving treatment for bleeding, via targeted transfusion strategies. Recently a new viscoelastic coagulation monitoring system, the VCM System, has been developed, which has several advantages over existing systems. The VCM system is a small, portable device, that is designed to be simple to operate and can be used to reliably perform viscoelastic...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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