Polycystic ovary syndrome and lung function: a Mendelian randomization study

We examined heterogeneity across SNPs to assess pleiotropy and performed MR methods that adjust for pleiotropy as sensitivity analyses.The MR estimate shows that PCOS is associated with a 10% higher risk of spirometric restriction (OR 1.10 [1.05 to 1.15]), with no indication of pleiotropy (Q test P= 0.86; I2= 0). Estimates were similar when using MR methods adjusting for pleiotropy and when limiting the analysis to non-asthmatics (OR 1.12 [1.06 to 1.18]) or SNPs significant in European women (OR 1.10 [1.04 to 1.16]). Effect estimates were similar in normal weight and overweight (>26 kg/m2) women (interaction P=0.89). There was no association between PCOS and airflow obstruction (OR 0.98 [0.94 to 1.02]).Our MR results suggest that PCOS increases the risk of spirometric restriction. Further studies are needed to investigate the possible underlying mechanism. (ALEC, EU Grant #633212)

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: van der Plaat, D., Minelli, C., Jarvis, D., Garcia-Aymerich, J., Gomez-Real, F., Leynaert, B. Tags: Genes and environment Source Type: research