Mitochondrial dysfunction activates MHC class I adaptive immune responses in lung aging

In conclusion, our findings show that dysfunctional mitochondria induce stress signaling to activate IP function and MHC I antigen presentation. In the aging lung defective mitochondrial function might thereby contribute to autoimmunity via altered MHC class I antigen presentation.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Meul, T., Wang, X., Angelidis, I., Berschneider, K., Schmitt, S., Zischka, H., Toerne, C. V., Hauck, S. M., Schiller, H. B., Meiners, S. Tags: Airway cell biology and immunopathology Source Type: research