Role of CBNAAT in Extrapulmonary Tuberculosis- An ongoing pilot study

We examined 191 samples during the period. Pleural fluid was the most common sample(30.9%) collected followed by lymph node aspirate(24.6%). The overall sensitivity and specificity of CBNAAT was determined to be 26.77%(95% CI 19.31%-35.35%) and 100%(95% CI 94.40%-100%). The low sensitivity could be due to the low sample size and majority of the sample being pleural fluid. The sensitivity and specificity of CBNAAT in relation to mycobacterial culture, however, was 76.47%(95% CI 50.1%-93.19%) and 87.93%(95% CI 82.14%-92.37%) respectively.The sensitivity and specificity of CBNAAT was at par in comparison to mycobacterial culture. However, both were highest for lymph node aspirate and pus samples and may be recommended in initial diagnosis in these cases.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research