Etiology and clinical characteristics of bronchiectasis in Taiwan: a multi-center cohort study

This study aims to determine etiology and clinical features of bronchiectasis in Taiwan.This multi-center cohort study investigated non-CF bronchiectasis patients newly diagnosed from 2002/1/1 to 2016/12/31. The clinical data was retrieved from five medical centers across Taiwan. The index date was bronchiectasis firstly diagnosed. Known diseases that existed before the index date were regarded as etiologies of bronchiectasis.A total of 15,729 adult patients with bronchiectasis were included. Idiopathic (32%) was the most common cause, followed by post-pneumonia (24%). Other causes included post-tuberculosis (12%), chronic obstructive pulmonary disease (14%), asthma (10%), gastroesophageal reflux disease (2%) and rheumatic diseases (2%). Age, gender, lung function and commorbidities were significantly different between idiopathic and known etiologies. 8,487 patients had sputum culture at diagnosis. Pseudomonas aeruginosa (5.3%) was the most common bacteria, followed by non-tuberculosis mycobacteria(NTM) (3.6%), Haemo. influenzae (3.4%) and Kleb. pneumoniae (3.1%), but 6,155(72.1%) with negative sputum culture. NTM ranked first in post-TB patients. Post-TB and post-pneumonia bronchiectasis patients had a higher frequency of chronic lung infection than other groups (p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research

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Publication date: Available online 21 February 2020Source: MethodsXAuthor(s): Paul O'Brien, Christopher Vinnard, Selvakumar SubbianABSTRACTTuberculous meningitis (TBM), caused by Mycobacterium tuberculosis (Mtb), is the deadliest form of tuberculosis in humans, particularly in children and the geriatric population. However, the host-pathogen interactions underlying TBM is not well understood. Rabbits are a valuable model system to study TB in humans. The rabbit model of TB recapitulates several pathophysiological characteristics, including heterogeneity, architecture, and development of granulomas at the site of infection ...
Source: MethodsX - Category: Science Source Type: research
Conclusion: The findings, such as the inverse relationship with tuberculosis treatment discontinuation in the group of people with comorbidity, reinforce the importance of integrated actions in health services to change the scenario of this challenging comorbidity.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Publication date: Available online 20 February 2020Source: The Lancet Global HealthAuthor(s): Xin Wang, You Li, Katherine L O'Brien, Shabir A Madhi, Marc-Alain Widdowson, Peter Byass, Saad B Omer, Qalab Abbas, Asad Ali, Alberta Amu, Eduardo Azziz-Baumgartner, Quique Bassat, W Abdullah Brooks, Sandra S Chaves, Alexandria Chung, Cheryl Cohen, Marcela Echavarria, Rodrigo A Fasce, Angela Gentile, Aubree GordonSummaryBackgroundSeasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-viru...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
We examined the effectiveness of brief cognitive-based psychotherapy plus standard case management in the prevention of further suicide attempts, clinical severity, and treatment adherence in a randomized clinical trial compared with standard ca...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news
Authors: Vitacca M, Lastoria C, Delmastro M, Fiorenza D, De Cata P, Fusar Poli B, Gilè S, Prometti P, Paneroni M, Bianchi C, Mandora E, Porri R, Fracchia C Abstract To date treatment protocols in Respiratory and or Internal departments across Italy for treatment of chronic obstructive pulmonary disease (COPD) patients at hospital admission with relapse due to exacerbation do not find adequate support in current guidelines. Here we describe the results of a recent clinical audit, including a systematic review of practices reported in literature and an open discussion comparing these to current real-life proce...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
We report an elderly male who presented with cough and fever and had pulmonary infiltrates suspicious of tuberculosis. Bronchoalveolar lavage microbiology including XpertMTB/Rif assay was non-contributory. Contrast enhanced computed tomography scan of abdomen revealed multiple non-enhancing lesions in the spleen. Ultrasound guided splenic aspirate revealed pus that was positive for Mycobacterium tuberculosis in XpertMTB/Rif assay confirming the diagnosis of tuberculosis. PMID: 32072799 [PubMed - in process]
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Authors: Rathi V, Ish P, Singh G, Tiwari M, Goel N, Gaur SN Abstract Non-anemic iron deficiency has been studied in heart failure, but studies are lacking in chronic obstructive pulmonary disease (COPD). The potential clinical implications of association of iron deficiency with the severity of COPD warrant research in this direction. This was an observational, cross-sectional study on patients with COPD to compare disease severity, functional status and quality of life in non-anemic patients with COPD between two groups - iron deficient and non-iron deficient. Stable non-anemic COPD with no cause of bleeding were e...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
ConclusionsFitness tracker sleep efficiency and wake counts demonstrate clinical utility as predictive of asthma-specific night-time wakening and daily FEV1. Fitness tracker sleep data demonstrated predictive capability for daily asthma outcomes.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
ConclusionThe prevalence rate of developmental disabilities in northeastern Taiwan was 11.36%. Low economic status, prematurity and/or small for gestational age and a history of underlying medical disorders were the main risk factors correlated with developmental disabilities. Taipei II is an easy-to-use and effective developmental surveillance tool for Taiwanese children.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Conclusions: Physician-diagnosed ACO patients had highest prevalence of current-smoker and their symptoms, lung function, and eosinophil counts were between the two conditions.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
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