Gene Signatures in Cutaneous Malignancies

AbstractPurpose of ReviewIn this review, we will discuss the recent advances in the identification of landmark gene signatures in cutaneous melanoma and in the discovery of those relevant to cutaneous squamous cell carcinoma (cSCC).Recent FindingsMelanoma and cSCC are the most important cutaneous malignancies when considering morbidity and mortality. They are responsible for the greatest number of skin cancer related deaths. Over the past several years, a number of gene signatures have been identified showing great promise in terms of tumor molecular classification and risk stratification of patients to anticipate best therapeutic modalities. These gene signatures have allowed a personalized medicine approach to a comprehensive decision-making process for these patients.SummaryPrediction of the prognosis and therapeutic response of patients with melanoma and high-risk cSCC will be aided by the elucidation and utilization of these gene signatures.
Source: Current Surgery Reports - Category: Surgery Source Type: research