Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice

Conclusions/interpretationThese data indicate that fenofibrate alters the pancreatic lipidome to a more anti-inflammatory and anti-apoptotic state. The beneficial effects on islet sympathetic nerve fibres and blood glucose homeostasis indicate that fenofibrate could be used as a therapeutic approach to improve blood glucose homeostasis and prevent diabetes-associated pathologies.
Source: Diabetologia - Category: Endocrinology Source Type: research