The gut microbiome in epilepsy

In this study, we analyzed and compared the intestinal microbiota composition of patients with idiopathic focal epilepsy (n = 30) and healthy volunteer group (n = 10) by 16s ribosomal DNA sequencing. Proteobacteria phylum was found to be higher in patients with epilepsy (25.4%) than in healthy volunteers group (1.5%). The genera of Campylobacter, Delftia, Haemophilus, Lautropia, Neisseria among Proteobacteria phylum were found to be statistically significantly higher in patients with epilepsy than in healthy volunteers (p 
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

Related Links:

An oral, inactivated enterotoxigenic Escherichia coli (ETEC) vaccine (ETVAX) is safe and immunogenic in children, according to a new phase-1/2 trial.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Although most patients with type 1 diabetes (T1D) retain some functional insulin-producing islet β cells at the time of diagnosis, the rate of further β cell loss varies across individuals. It is not clear what drives this differential progression rate. CD8+ T cells have been implicated in the autoimmune destruction of β cells. Here, we addressed whether the phenotype and function of autoreactive CD8+ T cells influence disease progression. We identified islet-specific CD8+ T cells using high-content, single-cell mass cytometry in combination with peptide-loaded MHC tetramer staining. We applied a new analyti...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease is caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), and increased CD4–CD8–B220–TCRαβ+ T cells (αβDNTs), in addition to the previously described features of an inverted CD4/CD8 ratio, CD4+ T lymphocytopenia, increased B cells, dysgammaglobulinemia, and decreased expression of the natural killer group 2, member D (NKG2D) recept...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 9 December 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Jingjing Guo, Geraldine W.N. Chia, Nikolay V. Berezhnoy, Amaury Cazenave-Gassiot, Staffan Kjelleberg, Jamie Hinks, Yuguang Mu, Thomas SeviourAbstractThe outer membrane (OM) is the first defence for Gram-negative bacteria against their environments making it important in strain improvement for sustainable biobutanol production. While modifying the OM structure using chemical additives could enhance microbial viability, there are currently no model systems that accurately describe OM responses to butanol. He...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Publication date: Available online 9 December 2019Source: PolymerAuthor(s): O.I. Timaeva, N.A. Arkharova, A.S. Orekhov, V.V. Klechkovskaya, S.P. Mulakov, G.M. Kuz'micheva, I.I. PashkinAbstractComposite hydrogels in the poly-N-vinylpyrrolidone – RE(NO3)3 × xH2O system with RE = La, Gd, Yb were prepared in various forms (native, native dried in the air, dried in air and ground into powder). They were studied by methods of wide- and small-angle X-ray scattering, differential scanning calorimetry, scanning electron microscopy, and electron microprobe analysis. The composition of native PVP and PVP with powd...
Source: Polymer - Category: Chemistry Source Type: research
The objective of this study was to evaluate tolerability and efficacy of synthetic cannabidiol in patients with pharmacoresistant epilepsy.Methods: In this prospective, open-label study (DRKS00013177), patients with pharmacoresistant epilepsy received synthetic cannabidiol in addition to their previously stable anticonvulsive treatment. Starting dose was 5 mg/kg/day, up-titrated to a maximum of 50 mg/kg/day. Primary efficacy endpoint was monthly frequency of motor seizures at 3 months.Results: Between April 2017 and May 2019, 35 patients were enrolled in the study. Mean age was 19.7 years (SD 14.6). Median motor seizure fr...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The post-partum period is an immunologically peculiar period in a woman's life. Indeed, most of the pregnancy-related immune changes gradually revert in the 12 months following delivery. Although the post-partum period has long been identified as a period of aggravation of autoimmune thyroid diseases, most of the currently available studies took into account the relationship between post-partum and autoimmune thyroiditis. More recently, the potential repercussions of the post-partum period on Graves' disease were also taken into account. The present mini review will briefly overview the most recent advances in our knowledg...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Hashimoto autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in the pediatric population. Development of AIT is mediated mainly by cellular immune response directed toward thyroid autoantigens, leading to inflammation and impaired function of thyroid gland. Both thyroid dysfunction and inflammation affect the metabolism of plasma lipoproteins. The alterations in lipid profile worsen with the advancement of hypothyroidism, ranging from discrete changes in euthyroid AIT patients, to atherogenic dyslipidemia in the overt hypothyroidism. In this review, characteristics of dyslipidemia in pediatric...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency and comprises a group of disorders with similar antibody deficiency but a myriad of different etiologies, most of which remain undefined. The variable aspect of CVID refers to the approximately half of patients who develop non-infectious complications in addition to heightened susceptibility to infection. The pathogenesis of these complications is poorly understood and somewhat counterintuitive because these patients that are defined by their immune futility simultaneously have elevated propensity for autoimmune disease. Ther...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionWhile characterizing the literature on pediatric polypharmacy in terms of the types of medication studied, we further identified substantive gaps within this literature outside of epilepsy and psychiatric disorders. Medications frequently identified in use of polypharmacy for treatment of epilepsy and psychiatric disorders reveal opportunities for enhanced medication management in pediatric patients.
Source: Pediatric Drugs - Category: Pediatrics Source Type: research
More News: Autoimmune Disease | Campylobacter | Epilepsy | Fusobacterium | Gastroenteritis | Infectious Diseases | Statistics | Study