Efficacy and Safety of Brexpiprazole for the Treatment of Agitation in Alzheimer's Dementia: Two 12-Week, Randomized, Double-Blind, Placebo-Controlled Trials.

CONCLUSIONS: Brexpiprazole 2 mg/day has the potential to be efficacious, safe, and well tolerated in the treatment of AAD. PMID: 31708380 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

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Resumen A pesar de que son ampliamente conocidos los perfiles de utilizaci ón de las benzodiazepinas (BZD) y los riesgos asociados, este conocimiento no ha conducido a visibles transformaciones que mejoren la seguridad de los tratamientos y la salud de los pacientes. Por tanto, es necesaria una mejor compresión del contexto de su utilización, con el fin de implementar a cciones educativas eficaces, tomar decisiones clínicas pertinentes y perfeccionar su regulación en los servicios de salud. Este artículo se propone caracterizar el perfil de utilización de benzodiazepinas en ...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
Resumo Este artigo tem por base uma investiga ção realizada entre novembro de 2013 e janeiro de 2017, na Universidade do Minho (Portugal), sobre os docentes da Universidade Óscar Ribas (UOR) (Angola). Foi alicerçado num referencial teórico, a Psicodinâmica do Trabalho de Christophe Dejours, e teve como objetivos analisar os sintomas biops icossociais e os sentimentos de prazer e/ou de sofrimento relacionados com o trabalho docente. Foi utilizada a metodologia quantitativa, que teve por base a aplicação de um questionário e duas escalas a 56 docentes da UOR. Veri...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
Insomnia and co-existing sleeplessness and musculoskeletal pain were inversely related to long-term recovery from chronic low back pain, a study found; relieving sleep problems may improve recovery.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Internal Medicine News Source Type: news
Abstract Schisandra sphenanthera Rehder&E.H. Wilson, Schisandraceae, is well known as a type of traditional medicine for the treatment of hepatitis, diarrhea and insomnia in Asia. It was also reported to have antiviral and anti-HIV activities. Using various chromatographic resins and isolation techniques, a new lignan (1), erythro-4-(3,4-dimethoxyphenyl)-4-hydroxy-3-methylbutan-2yl-3,4-dimethoxybenzoate, along with fifteen known compounds, were isolated from fruits of S. sphenanthera. The structures of the compounds were identified by extensive spectroscopic and spectrometric methods including 1D and 2D NMR and MS data...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Condition:   Mild Cognitive Impairment Interventions:   Drug: T-817MA;   Drug: Placebo Sponsor:   FUJIFILM Toyama Chemical Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Irene Taylor Brodsky's doc reveals her deaf son's triumph and her deaf dad's Alzheimer's challenges ... "If you told my dad 50 years ago that there would be this tool that would allow him to hear, ...
Source: AARP.org News - Category: American Health Source Type: news
In conclusion, DZSM capsules protected against cognitive defects of AD through scutellarin-mediated acceleration of Aβ aggregation into fibrils or protofibrils and reduction of soluble Aβ oligomers, thus suggesting potential clinical applications of DZSM capsules and scutellarin in the treatment of AD. PMID: 31810113 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Abstract Berberine is a natural isoquinoline alkaloid isolated from the Rhizoma coptidis. Recent advances in research throw more lights of its beneficial role towards Alzheimer's disease (AD), including promoting β-amyloid (Aβ) clearance, as well as inhibiting Aβ production in the triple-transgenic mouse model of Alzheimer's disease (3×Tg AD). However, it remains unclarified if berberine has an effect on tau pathology. According to our study, berberine did not only significantly improve 3×Tg AD mice's spatial learning capacity and memory retentions, but also attenuated the hyperphosphory...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
ConclusionThe HGT carried out with the ALZENTIA system proved to be a reliable screening test to identify individuals with MCI from an aging cohort.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
CONCLUSION: This study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail. PMID: 31810524 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
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