Examining muscle relaxant dose, risk of encephalopathy in patients with CKD

(JAMA Network) Whether a higher or lower dose of the muscle relaxant baclofen was associated with 30-day risk of hospitalization with encephalopathy (defined as a main diagnosis of delirium, disorientation, transient alteration of awareness, transient ischemic attack or an unclear diagnosis of dementia) among newly prescribed patients with chronic kidney disease was the focus of this observational study with nearly 16,000 older adults.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionsHHS/DKA occurred mostly in T1D and younger patients. However, both also occurred in T2D, which is of great importance in the treatment of diabetes. Better education programmes are necessary to prevent decompensation and comorbidities.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Cognition is an important function of the brain that enables us to acquire and process information, to enhance our understanding of thoughts, experiences, and our senses. Any condition that affects our ability to think, reason, memorize, or be attentive affects our cognitive ability. Some cognitive decline is a normal part of aging, but there are many things you can do to prevent or forestall cognitive changes as you age, including when planning for surgery. Older adults are having more surgical procedures As our population ages and medicine and healthcare advances, more older adults are likely to develop serious condition...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Healthy Aging Managing your health care Memory Neurological conditions Prevention Surgery Source Type: blogs
“The loneliest moment in someone’s life is when they are watching their whole world fall apart, and all they can do is stare blankly.” – F. Scott Fitzgerald Loneliness is never easy to endure, yet during times of mandatory social isolation and distancing, such as millions of Americans are experiencing during the COVID-19 pandemic, it can be particularly damaging. Among its many effects, loneliness can exacerbate and bring upon a host of mental and physical conditions. Social Isolation and Loneliness May Increase Inflammation A study by researchers at the University of Surrey and Brunel University Lo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Self-Help coronavirus COVID-19 Loneliness social distancing Source Type: blogs
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia. To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence? https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/ Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study investigated associations of the urinary albumin : creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) with the WMH volume to intracranial volume (WMHV : ICV) ratio, and the association of the combination of UACR and the WMHV : ICV ratio with cognitive decline and mortality risk. The geometric mean of the WMHV : ICV ratio was 0.223% in the entire study population, and increased significantly with higher UACR levels after adjusting for potential confounding factors (0.213% for normoalbuminuria, 0.248% for microalbuminuria, and 0.332% for macroalbuminuria; Ptrend=0.01). In contrast, there was n...
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
AbstractIt has been accepted that kidney function is connected with brain activity. In clinical studies, chronic kidney disease (CKD) patients have been found to be prone to suffering cognitive decline and Alzheimer ’s disease (AD). The cognitive function of CKD patients may improve after kidney transplantation. All these indicators show a possible link between kidney function and dementia. However, little is known about the mechanism behind the relation of CKD and AD. This review discusses the associations b etween CKD and AD from the perspective of the pathophysiology of the kidney and complications and/or concomit...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
This study aimed to establish risk prediction models for dementia and frailty. A sample of 2905 community-dwelling older adults aged ≥58 years using the Taiwan Longitudinal Study on Aging (TLSA) survey was adapted and analyzed for this study. Risk scores were estimated by stepwise logistic regression. In models adjusted for covariates, increased age, female sex, no dental prosthesis (adjusted Odds ratio [adjOR], 1.61; 95% confidence interval [CI], 1.11–2.35), diabetes mellitus, chronic kidney disease, and an increased Oral Health Impact Profile (OHIP)-7T Q3 score (adjOR, 1.33; 95% CI, 1.19–1.49) ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
An 85-year-old Japanese woman was admitted to our hospital because of a lumbar compression fracture. She spent most of her time in bed because of immobilization due to Alzheimer's dementia. She did not have any past history of connective tissue disease or chronic kidney disease and did not have a history of intramuscular injection. On physical examination, small nodules were palpable beneath the skin on her buttocks bilaterally. Her serum-corrected calcium and phosphate levels were 9.1 mg/dL and 3.5 mg/dL, respectively.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communications to the Editor Source Type: research
Publication date: Available online 20 February 2020Source: IDCasesAuthor(s): Heather L. Clark, Hugo E. Valencia, Jennifer J. Findeis-Hosey, Steve N. GeorasAbstractAspergillus molds are ubiquitous environmental molds that can cause devastating invasive infections in immunocompromised patients. These infections often go unrecognized in critically ill patients. This case describes a 68 year-old female resident of a long-term nursing facility with history of dementia, nonalcoholic fatty liver disease with cirrhosis, chronic kidney disease stage III and insulin-dependent type 2 diabetes who presented with vomiting, diarrhea and...
Source: IDCases - Category: Infectious Diseases Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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