Contribution of Inflammation and Bone Destruction to Pain in Arthritis: A Study in Murine Glucose ‐6‐Phosphate Isomerase–Induced Arthritis

ConclusionPain ‐related behaviors precede and outlast self‐limiting arthritis. In nonremitting arthritis with enhanced bone destruction, mainly local thermal, but not local mechanical, hyperalgesia was aggravated. The up‐regulation of ATF‐3 indicates an early and persisting affection of sensory neurons by G6PI‐induced arthritis.

Source: Arthritis and Rheumatology - November 8, 2019 Category: Rheumatology Authors: Matthias Ebbinghaus, Sylvia M üller, Gisela Segond von Banchet, Annett Eitner, Isabel Wank, Andreas Hess, Ingrid Hilger, Thomas Kamradt, Hans‐Georg Schaible Tags: Original Article Source Type: research