Causes and Metabolic Consequences of Gynecomastia in Adult Patients.

Conclusion: The development of GM in adults might be an important symptom of an underlying gonadal disease. Moreover, it could be associated with an increased risk of metabolic disturbances. Our results support the need of detailed laboratory and hormonal investigations in patients with GM including targeted screening for metabolic disturbances. Further longitudinal studies are needed to evaluate the long-term consequences of sex hormones imbalance on cardiovascular morbidity and mortality in adults with GM. PMID: 31687020 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research

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We examined 4 pathologic conditions of IR in humans to examine pathways controlling lipid metabolism and gluconeogenesis.METHODS Cross-sectional study of severe receptor IR (INSR, n = 7) versus postreceptor IR that was severe (lipodystrophy, n = 14), moderate (type 2 diabetes, n = 9), or mild (obesity, n = 8). Lipolysis (glycerol turnover), hepatic glucose production (HGP), gluconeogenesis (deuterium incorporation from body water into glucose), hepatic triglyceride (magnetic resonance spectroscopy), and hepatic fat oxidation (plasma β-hydroxybutyrate) were measured.RESULTS Lipolysis was 2- to 3-fold higher in INSR ver...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Western diet–fed (WD-fed) mice exhibited increased myenteric neuronal pyroptosis, delayed colonic transit, and impaired electric field stimulation–induced colonic relaxation responses. WD incr...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Authors: Pirola CJ, Sookoian S Abstract INTRODUCTION: Fatty liver disease, defined by the presence of liver fat infiltration, is part of a cluster of disorders that occur in the context of metabolic syndrome. Epigenetic factors - defined as stable and heritable changes in gene expression without changes in the DNA sequence - may not only play an important role in the disease development in adulthood, but they may start exerting their influence in the prenatal stage. AREAS COVERED: By using systems biology approaches, we review the main epigenetic modifications and highlight their likely roles in the pathogenesi...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Children who are overweight or obese are at a higher risk of several diseases and are more likely to be overweight or obese in adulthood. Physical inactivity among children and adolescents is one of the major causes of the prevalence of overweight and obes...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 1 June 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Procolo Di Bonito, Lucia Pacifico, Maria Rosaria Licenziati, Claudio Maffeis, Anita Morandi, Melania Manco, Emanuele Miraglia Del Giudice, Anna Di Sessa, Giuseppina Campana, Nicola Moio, Marco Giorgio Baroni, Claudio Chiesa, Giovanni De Simone, Giuliana Valerio, Claudia Forziato, Luisa Gilardini, Sandro Loche, Gianluca Tornese
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Conditions:   Covid-19;   Obesity, Childhood;   Lifestyle;   Lifestyle, Healthy;   Overweight, Childhood;   Children, Only;   Family Intervention:   Other: Exposure to the Dutch measures due to the Covid-19 pandemic. Sponsor:   Maastricht University Medical Center Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Overweight and Obesity;   Emergencies Interventions:   Device: Dynamic ultrasound-guided short-axis needle tip navigation;   Other: Standard technique of placing a PVC Sponsor:   University Hospital, Linkoeping Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Obesity Intervention:   Behavioral: Smartphone + Text Messaging with Health Coach Sponsor:   Ohio State University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Bariatric Surgery;   Micronutrient Deficiencies;   Obesity Intervention:   Procedure: Gastric Bypass, Sleeve Gastrectomy Sponsor:   Region Östergötland Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Tzortzis V, Samarinas M, Zachos I, Oeconomou A, Pisters LL, Bargiota A Abstract Prostate cancer is the most common cancer among men and androgen deprivation therapy (ADT) is the most effective treatment for this disease. The cornerstone of the treatment of prostate cancer is inhibition of testosterone production which interrupts testosterone-induced growth of the prostate tumor. The dramatic decrease in testosterone levels, however, has several undesirable effects on the metabolic profile and bone metabolism and can also lead to fatigue, loss of libido, gynecomastia, and anemia, provoke vasomotor flushing,...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
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