Aminopropyl-silica functionalized with halogen-reactive compounds for antimicrobial applications

Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Irina Zarafu, Ali Abed Jebur Al Taweel, Carmen Limban, Marcela Popa, Luminița Măruțescu, Mariana Carmen Chifiriuc, Gratiela Gradisteanu Pircalabioru, Daniela Culiță, Corneliu Ghica, Petre IonitaAbstractAminopropyl-silica nanoparticles S0 were obtained and further functionalized with eight halogen-reactive organic compounds 1–8, leading to the S1–S8 hybrid organic-inorganic materials, with spherical morphology and having a 50–200 nm size, as showed TEM analysis. These were further characterized by IR and DLS. Biological assays were performed using five microbial strains, belonging to species frequently encountered in the aetiology of human infections (Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans). The obtained materials exhibited promising antimicrobial properties, being active against planktonic, but particularly on biofilm-embedded cells. Among the tested hybrid nanomaterials, S6 seemed to exhibit the most promising antimicrobial profile.Graphical abstract
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research