Outbreaks of severe pneumococcal disease in closed settings in the conjugate vaccines era, 2010 –2018: A systematic review to inform national guidance in the UK

Outbreaks of severe pneumococcal disease occur sporadically and can affect large numbers of individuals, although they are less frequent compared to the pre-antibiotic era.1 The responsible pathogen, Streptococcus pneumoniae, is a Gram-positive bacterium that commonly colonises the nasopharyngeal tract, especially in young children. Occasionally, however, it can invade locally to cause mucosal infections including sinusitis, otitis media or pneumonia. Rarely, invasion of the bloodstream can lead to more serious infections, including septicaemia and meningitis.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research

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Authors: Casagrande Pierantoni D, Bernardo M, Mallardo E, Carannante N, Attanasio V, Corte L, Roscini L, Di Fiore L, Tascini C, Cardinali G Abstract A correct, fast, reliable identification method is pivotal in nosocomial environments to guide treatment strategies, whereas misidentification might lead to treatment failure. For routine identifications the Vitek system and CHROMagar are widely used but not always reliable, especially now with an increasing number of new emerging fungal pathogens that need careful identification. Here we describe two cases of candidemia, due to Candida palmioleophila previously miside...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
CONCLUSION: This study can contribute to decision-making about potential prices for a chikungunya vaccine once it becomes available in Brazil. We demonstrated the relevance of the anchoring effect as a possible influence applied to the maximum value of the WTP associated with respondents' preference for a new vaccine. Finally, we encourage the development of a chikungunya virus vaccine to benefit the Brazilian population. PMID: 31815561 [PubMed - as supplied by publisher]
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
A multivalent HIV vaccine that consists of envelope protein (gp120 Env) and either DNA or NYVAC vectors during priming leads to early and potent IgG-binding antibody responses, according to results from the HIV Vaccine Trials Network (HVTN).Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: HIV/AIDS News Source Type: news
Publication date: Available online 9 December 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Qingtao Liu, Jing Yang, Xinmei Huang, Yuzhuo Liu, Kaikai Han, Dongmin Zhao, Lijiao Zhang, Yin LiAbstractAvian influenza subtype H9N2 infection is a mild but highly contagious disease that is associated with a decrease in the efficacy of vaccine interventions, and an increase in susceptibility to secondary infections in poultry. However, the immune evasion mechanism of H9N2 avian influenza viruses (AIVs) in chickens is poorly understood. Dendritic cells (DCs) are immune cells of major importance, involved in innate ...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Canadian Journal of Microbiology, e-First Articles. Zika virus (ZIKV) is a mosquito-borne virus that was first isolated from Zika forest, Uganda, in 1947. Since its inception, major and minor outbreaks have been documented from several parts of world. Aedes spp. mosquitoes are the primary vectors of ZIKV, but the virus can also be transmitted through sexual practices, materno-fetal transmission, and blood transfusion. The clinical presentations of symptomatic ZIKV infections are similar to dengue and chikungunya, including fever, headache, arthralgia, retro-orbital pain, conjunctivitis, and rash. ZIKV often causes mild ill...
Source: Canadian Journal of Microbiology - Category: Microbiology Authors: Source Type: research
Contributor : Smita S IyerSeries Type : Expression profiling by high throughput sequencingOrganism : Macaca mulattaGenerating durable humoral immunity through vaccination depends upon effective interaction of follicular helper T cells (Tfh) with germinal center (GC) B cells. Th1 polarization of Tfh cells is an important process shaping the success of Tfh-GC B cell interactions by influencing co-stimulatory and cytokine-dependent Tfh help to B cells. However, the question remains whether adjuvant-dependent modulation of Tfh cells enhances HIV-1 vaccine-induced anti-Envelope (Env) antibody responses. We investigated whether ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Macaca mulatta Source Type: research
We present the case of an 11 year old male who was found to have a right-sided, post-obstructive pneumonia secondary to an aspirated FB obstructing the bronchus intermedius. Relief of the obstruction allowed for rapid, endobronchial spread of infection and within 6 hours of FB removal, our patient developed severe ARDS requiring initiation of extracorporeal membrane oxygenation (ECMO). Streptococcus constellatus was isolated from lower respiratory cultures obtained during initial bronchoscopy.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
[CAJ News] Kinshasa -MORE than 500 people have died this year from a worsening outbreak of cholera wreaking havoc in Central and West Africa.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[New Zimbabwe] Britain has donated £49 million towards food security in Zimbabwe and a further £5 million towards efforts to combat cholera outbreaks in its troubled former colony.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
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Source: Nursing Made Incredibly Easy - Category: Nursing Tags: Department: Ask an Expert Source Type: research
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