Cancers, Vol. 11, Pages 1647: Tumor and Cerebrospinal Fluid microRNAs in Primary Central Nervous System Lymphomas

In conclusion, tissue miR-155, miR-196b, miR-9, miR-125b, and miR-let-7b expression profiles differentiate PCNSL from n-ML. PCNSL CSFs and the relevant biopsy samples are characterized by specific, different microRNA profiles. A logistic regression model is proposed to discriminate between PCNSL and non-malignant brain lesions. None of the examined microRNAs influenced overall survival of PCNSL patients. Further ongoing developments involve next generation sequencing-based profiling of biopsy and CSF samples.

Source: Cancers - October 24, 2019 Category: Cancer & Oncology Authors: Michalina Zajdel Grzegorz Rymkiewicz Maria Sromek Maria Cieslikowska Pawel Swoboda Mariusz Kulinczak Krzysztof Goryca Zbigniew Bystydzienski Katarzyna Blachnio Beata Ostrowska Anita Borysiuk Agnieszka Druzd-Sitek Jan Walewski Magdalena Chechlinska Jan Kon Tags: Article Source Type: research