High incidence of heparin-induced allergic delayed-type hypersensitivity reactions in pregnancy

Conclusions: Among patients receiving long-term heparin anticoagulation during pregnancy, heparin-induced skin lesions are frequent (incidence, 19.8%) and are all caused by allergic DTH reactions. Nadroparin has the highest frequency of skin lesions (approximately 65% at 100 days), which is significantly higher than that of dalteparin (HR, 26.7). Therefore nadroparin use should be avoided in pregnancy when possible.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research