A yeast phenomic model for the influence of Warburg metabolism on genetic buffering of doxorubicin

ConclusionsWarburg status alters the genetic network required for yeast to buffer doxorubicin toxicity. Integration of yeast phenomic and cancer pharmacogenomics data suggests evolutionary conservation of gene-drug interaction networks and provides a new experimental approach to model their influence on chemotherapy response. Thus, yeast phenomic models could aid the development of precision oncology algorithms to predict efficacious cytotoxic drugs for cancer, based on genetic and metabolic profiles of individual tumors.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research