Chlamydia Biology

Chlamydia BiologyMing Tan, Johannes H. Hegemann and Christine Sütterlin present a new book on Chlamydia Biology: From Genome to Disease This book provides an up-to-date review of the clinical infections caused by the two main human pathogens C. trachomatis and C. pneumoniae, as well as chapters on veterinary Chlamydia species and Chlamydia-related bacteria. Multiple chapters cover cutting-edge developments in Chlamydia research, from the basic biology of the intracellular chlamydial infection to the host immune response and work towards a Chlamydia vaccine. Also highlighted are recent advances in chlamydial genetics and genomics, which have transformed the field. For the first time in a Chlamydia book, there are chapters on Chlamydia cell division and differentiation and Chlamydia infections and the microbiota, which are two hot areas of research. Each of the nineteen chapters is written by experts, who have made major contributions through their work and come from different research groups to ensure a broad and fresh perspective. This book will be of interest to Chlamydia researchers, microbiologists, cell biologists, infectious disease clinicians, public health professionals and government policy makers. It will be especially useful for newcomers to the Chlamydia field, who will find a current and comprehensive summary of Chlamydia research in one volume read more ...Chlamydia Biology: From Genome to DiseaseEdited by: Ming Tan, Johannes H. Hegemann and Christine Sü...
Source: Microbiology Blog: The weblog for microbiologists. - Category: Microbiology Source Type: blogs

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In this study, we evaluated a novel multiplex real-time PCR melting curve assay method for the simultaneous detection of 9 STD pathogens, including Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum, and herpes simplex virus.Methods: The analytical performance of the method, including its limit of detection (LOD), specificity, repeatability, and effect on different DNA extraction kits were evaluated. Additionally, we obtained 1,328 clinical specimens from 3 hospitals to detect the 9 STD pathogens using multiplex real-time...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Trichomonas vaginalis (TV) is a protozoan flagellate which usually dwells in the urogenital tract of humans. It is considered as a major cause of sexually transmitted disease (STD) (Satterwhite et al. 2013). TV is more prevalent than Chlamydia trachomatis, Neisseria gonorrhoeae, and syphilis altogether (World Health Organization, 2011). However, it is excluded from public health STD awareness programs and is considered a neglected parasitic infection (www.cdc.gov/parasites/npi). It is not a reportable infection and approximately 250 million new cases occur every year (World Health Organization, 2011).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
Publication date: Available online 7 November 2019Source: Microbial PathogenesisAuthor(s): Loubna EL Yazouli, Fouad Seghrouchni, Hicham Hejaji, Mohamed Bouazza, Aziz Aroussi Alami, Nadia Dakka, Fouzia RadouaniAbstractBackgroundChlamydia pneumoniae is an obligate intracellular bacterium that activates cell mediated immune responses; several investigations have demonstrated its strong implication in atherosclerosis.ObjectivesThe main objective of our study was to explore the cell-mediated immune response to C. pneumoniae infection in patients with atherosclerosis by evaluating CD14, CD8 and CD4 expression.MethodsThis investi...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
by Gertrud U. Rey Australian koalas are currently being invaded by koala retrovirus A (KoRV-A), a virus that causes an AIDS-like immunodeficiency and makes infected koalas more susceptible to cancers and opportunistic infections such as chlamydia. Retroviruses owe their name to their replication cycle, because their RNA genomes are reverse transcribed into DNA which is […]
Source: virology blog - Category: Virology Authors: Tags: Basic virology Gertrud Rey Information genome integration koala retrovirus KOR-A piRNA piwi protein retrotransposon rna silencing unspliced RNA viral viruses Source Type: blogs
(Umea University) Researchers at Ume å University (Sweden), in collaboration with researchers at the University of Maryland and Duke University (USA), now for the first time successfully performed targeted gene mutation in the zoonotic pathogen Chlamydia caviae.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In this study, an isobaric tags for relative and absolute quantitation (iTRAQ)-based quantitative proteomics analysis was performed to identify differentially expressed proteins between TC0668 wild-type (TC0668wt) and TC0668 mutant (TC0668mut) strains at 6, 12, 18, and 24 h post-infection (p.i.). Of the 550 proteins differentially expressed at 18 h p.i., 222 and 328 were up-regulated and down-regulated, respectively, inTC0668mut-infected cells. The expression of seven up-regulated proteins (encoded by SRPRB, JAK1, PMM1, HLA-DQB1, THBS1, ITPR1, and BCAP31) and three down-regulated proteins (encoded by MAPKAPK2, TRAFD1, and ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract Given the high burden of HIV and other sexually transmitted infections (STIs) among female sex workers (FSW) and their potential role in bridging HIV/STIs into the general population, estimating the prevalence of HIV/STIs among FSW is essential for future research and policy developments. This systematic review and meta-analysis synthesize the available HIV/STIs data among FSW in Iran. We searched MEDLINE, PsycINFO, CINAHL, Embase, Web of Science, Google Scholar, and Iranian databases from inception through to January 2018. Inclusion criteria were original quantitative studies that measured HIV/STIs preva...
Source: Archives of Sexual Behavior - Category: Psychiatry & Psychology Authors: Tags: Arch Sex Behav Source Type: research
Condition:   Early Pregnancy Intervention:   Diagnostic Test: cervicovaginal culture and qPCR and serum qPCR Sponsor:   Fayoum University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Extragenital manifestations of Chlamydia trachomatis infection can be challenging to diagnose. A previously healthy 33-year-old man presented with pericarditis recurring despite anti-inflammatory therapy and progressing to cardiac tamponade. Pericardiocentesis yielded bloody-appearing fluid with increased neutrophils and negative standard cultures. The patient reported recent unprotected sexual exposure, and urine nucleic acid amplification test detected C. trachomatis. He had no urogenital, ocular, or joint symptoms. The result of an extensive workup for other causes of pericarditis was negative, including HLA-B27 testing...
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Case Reports Source Type: research
Authors: Vuylsteke B, Reyniers T, De Baetselier I, Nöstlinger C, Crucitti T, Buyze J, Kenyon C, Wouters K, Laga M Abstract INTRODUCTION: Pre-Exposure Prophylaxis (PrEP) is highly effective in reducing the risk for HIV infection among men who have sex with men (MSM) and may have an important impact in slowing down the HIV epidemic. Concerns remain however about low adherence, increased risk behaviour and reduced condom use when using PrEP. The aim of this study was to assess these factors prospectively among MSM using daily and event-driven PrEP in Belgium. METHODS: An open-label prospective cohort study wa...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
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