Changes in taste among pediatric patients with cancer and hematopoietic stem cell transplantation recipients

ConclusionsThe experience of changes in taste was common yet highly variable in its presentation and resultant changes in food preferences. Taste changes did not always resolve soon after treatment completion. Future research should identify ways to manage this symptom in pediatric cancer patients.
Source: Quality of Life Research - Category: Health Management Source Type: research

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This article discusses the historic context of HDM-ASCT, the modern role of HDM-ASCT given the availability of highly sensitive MRD testing, and the likely future of quadruplet treatment. In summary, patients who attain deep responses using IMiD- and PI-based regimens may not require early HDM-ASCT. A delayed approach to this treatment is acceptable, and might be preferred by patients. PMID: 31730582 [PubMed - in process]
Source: Clinical Advances in Hematology and Oncology - Category: Cancer & Oncology Tags: Clin Adv Hematol Oncol Source Type: research
Publication date: Available online 16 November 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Fabianne Carlesse, Liane Esteves Daudt, Adriana Seber, Álvaro Pimenta Dutra, Analy Salles de Azevedo Melo, Belinda Simões, Carla Macedo, Carmem Bonfimi, Eliana Benites, Lauro Gregianin, Marjorie Vieira Batista, Marcelo Abramczyk, Vivian Tostes, Henrique Lederman, Maria Lúcia de Martino Lee, Sandra Logetto, Cláudio Galvão, Arnaldo Lopes ColomboAbstractIn the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infec...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
ConclusionsThese data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Conditions:   Acute Myeloid Leukemia (AML);   Cancer Interventions:   Drug: Venetoclax;   Drug: Azacitidine;   Other: Best Supportive Care (BSC) Sponsor:   AbbVie Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Over the last decade, incrementally improved xenograft mouse models, which support the engraftment and development of a human hemato-lymphoid system, have been developed and represent an important fundamental and preclinical research tool. Immunodeficientmicecan be transplanted with human hematopoietic stem cells (HSCs) and this process is accompanied by HSC homing to the murine bone marrow. This is followed by stem cell expansion, multilineage hematopoiesis, long-term engraftment, and functional human antibody and cellular immune responses. The most significant contributions made by these humanized mice ...
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Biochem Pharmacol Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Authors: Merker M, Meister MT, Heinze A, Jarisch A, Sörensen J, Huenecke S, Bremm M, Cappel C, Klingebiel T, Bader P, Rettinger E Abstract Prognosis of refractory childhood cancers despite multimodal treatment strategies remains poor. Here, we report a single center experience encountered in 18 patients with refractory solid malignancies treated with adoptive cellular immunotherapy (ACI) from haploidentical or matched donors following hematopoietic stem cell transplantation. While seven patients were in partial and six in complete remission (CR), five patients suffered from relapsed diseases at the time of ACI...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Severe cytokine release syndrome (CRS) may occur after T ‐cell‐replete haploidentical stem cell transplantation and conditions nonrelapse mortality. Disease burden and HLA mismatch in the graft‐vs‐host‐disease direction are the main factors affecting the occurrence of severe CRS. AbstractCytokine release syndrome (CRS) represents a life ‐threatening side effect after haploidentical stem cell transplantation (Haplo‐SCT) with posttransplant cyclophosphamide (PT‐Cy). Factors predictive of CRS development is still a matter of debate. We retrospectively analyzed 102 consecutive patients receiving a bone marrow (...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 6 November 2019Source: The Lancet HaematologyAuthor(s): Sandra Cohen, Jean Roy, Silvy Lachance, Jean-Sébastien Delisle, Anne Marinier, Lambert Busque, Denis-Claude Roy, Frédéric Barabé, Imran Ahmad, Nadia Bambace, Léa Bernard, Thomas Kiss, Philippe Bouchard, Pierre Caudrelier, Sévérine Landais, Fannie Larochelle, Jalila Chagraoui, Bernhard Lehnertz, Sophie Corneau, Elisa TomelliniSummaryBackgroundBenefits of cord blood transplantation include low rates of relapse and chronic graft-versus-host disease (GVHD). However, the use of cord blood i...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: Available online 5 November 2019Source: Stem Cell ResearchAuthor(s): Mireia Castillo-Martin, Nataliya Gladoun, Dan Han, Adolfo Firpo-Betancourt, Jose M. Silva, Carlos Cordon-CardoAbstractThe last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a malignancy during their life time; usually hematological tumors, but solid neoplasms may also develop, which in certain instances are donor-derived. It has also been well d...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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