Unravelling fatty liver haemorrhagic syndrome: 2. Inflammation and pathophysiology.

Unravelling fatty liver haemorrhagic syndrome: 2. Inflammation and pathophysiology. Avian Pathol. 2019 Oct 17;:1-37 Authors: Shini S, Shini A, Bryden WL Abstract To study the role of inflammation in the pathophysiology of the fatty liver haemorrhagic syndrome (FLHS), mature laying hen were treated with oestrogen (β-estradiol-17-dipropionate or E2) and challenged with lipopolysaccharide (LPS). Oestrogen injections induced FLHS, but the incidence and severity of the condition was increased with a combination of E2 & LPS. Hepatic mRNA levels of the genes encoding key regulators of inflammation such as interleukin-1β (IL-1β), interleukin-6 (IL-6) and interleukin-18 (IL-18) were evaluated. The expression of IL-6 mRNA in hepatocytes of all treated groups (E2, LPS and E2 & LPS hens) was elevated from 6 to 56 fold (P < 0.01), when compared to baseline and control values, with the highest fold change at 3 h post-treatment. The mRNA levels for IL-1β were better expressed at 24 h post-treatments with E2, LPS and E2 & LPS. The expression of IL-18 mRNA in the liver tissue was lower than IL-1β and IL-6 mRNA in all treated birds. At 24 h post-treatments, total white blood cell (WBC) counts and fibrinogen levels were elevated (P < 0.05) in E2, LPS and E2 & LPS treated hens. Histologically, livers of hens from E2 and E2 & LPS treated groups revealed inflammatory alterations with areas showing mononuclear a...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research