In vitro activity of ferroquine against artemisinin-based combination therapy (ACT)-resistant Plasmodium falciparum isolates from Cambodia

ConclusionsFerroquine exerts promising efficacy against ACT-resistant isolates. WhereasPfpm2 amplification was associated with the highest parasite tolerance to ferroquine, the susceptibility range observed was in accordance with those measured in ACT resistance-free areas. This enables consideration of ferroquine as a relevant therapeutic option against ACT-resistant malaria.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research