Management of oral anticoagulation in very old patients with non valvular atrial fibrillation related acute ischemic stroke

AbstractThe optimal management of oral anticoagulation (OAC) in the acute phase of non valvular atrial fibrillation (NVAF)-related acute ischemic stroke (AIS) remains controversial, especially in very old patients. Therefore, the aim of our study was to evaluate the practical management of OAC in this context. We conducted an observational retrospective study on patients 85-years old and older admitted to two Italian hospitals for NVAF-related AIS. For each patient, clinical and brain computed tomography data were recorded. Type of OAC (vitamin K antagonists, VKAs or Direct Oral Anticoagulants, DOACs), dosage and starting day after AIS were registered. For each patient 90-day all cause mortality, stroke recurrence, any bleeding and modified Rankin scale (mRS) were reported. One-hundred-seventeen patients, with mean age 89.2  ± 3.4 years, were enrolled. In-hospital and 90-day mortality (out of 109 patients) were 6% and 19.7%, respectively. OAC was started in 93 patients (80.5%), on average after 6 ± 3 days from the acute event. Of them, 88 patients (94.6%) received DOACs, while 5 (5.4%) received VKAs. Patien ts receiving OAC were significantly younger and suffering from less severe stroke compared with patients who did not receive OAC. Patients receiving OAC presented a reduced in-hospital (2.2% vs. 20.8%, p 
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research

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Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): Ryoiti KiyamaAbstractBackgroundGreen tea is produced from the tea plant Camellia sinensis without fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea consti...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Authors: Gatti M, Raschi E, De Ponti F Abstract BACKGROUND: The management of Klebsiella pneumoniae carbapenemase producing (KPC) infections represents a major challenge. Several safety and efficacy concerns are shared by available antibiotics used in KPC infections, leading to the occurrence of serious adverse drug reactions (ADRs), with ceftazidime-avibactam possibly showing a more favourable risk-benefit profile. We investigated the potential impact of resistance on ADR reports in countries with different prevalence of KPC isolates (Italy vs. United Kingdom [UK]), and described safety profile of newer and older ...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
This study sought to describe a single center's experience with transcatheter mitral valve-in-valve (TM-ViV) implantation. METHODS: Consecutive patients who had TM-ViV due to degenerative biological valve prosthesis at a single center during a 4-year period were identified from a prospectively maintained database. Operative outcomes were assessed both in-hospital and at 30 days. The primary outcome was in-hospital mortality. Secondary outcomes included valve function, functional status, and quality of life at follow-up. RESULTS: Mean (± standard deviation) patient age was 69 ± 12 years and all patient...
Source: The Journal of Invasive Cardiology - Category: Cardiology Tags: J Invasive Cardiol Source Type: research
This study aimed to evaluate the prognostic role of NLR, PLR, and LMR in PE. A total of 103 PE cases from a cardiology department were included in the study. Control group consisted of 102 patients selected from outpatient clinics other than cardiology, cardiovascular surgery, and chest diseases. We retrospectively evaluated demographic and clinical characteristics, treatments, laboratory and imaging findings, and outcomes of patients. The median follow-up of PE patients was 39 months, and the 5-year overall survival probability was 73.8%. Out of 103 patients, 20 were classified as high risk PE cases (19.4%). Thrombolytic ...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Publication date: 25 December 2019Source: Journal of Industrial and Engineering Chemistry, Volume 80Author(s): Pham Thi My Phuong, Hyun Jeong Won, Yeon Jeong Oh, Hyoung Sin Lee, Kang Dae Lee, Sung Young ParkAbstractThe present study aimed to develop a bio-adhesive material with excellent hemostatic and rapid wound healing properties using a catechol moiety (2chloro-3′,4′-dihydroxyacetophenone) conjugated to poly(dimethyl amino ethyl methacrylate-co-t-butyl methacrylate) [poly(DMA-co-t-BMA)-2-chloro-3′,4′-dihydroxyacetophenone (CA), C-PDB]. The desired glue matrix was formed by crosslinking between C...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: Available online 15 November 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Xin-Yu Wang, Xin-Ming Xie, Li-Qing Wang, Jun-Feng Su, Yan-Dong Guo, Ru MuAbstractRejuvenator-containing microcapsules for spontaneously healing microcracks in bitumen have been developed and are already commercially available. Such smart self-healing approaches are promising for use in developing long-life pavements. The aim of this work was to investigate the rheological behavior of bitumen blended with self-healing microcapsules effected by physical and chemical interface structures. Based...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Conclusion: The DIDC appears to be the most feasible model to visualize margins and necrosis zones after microwave ablation, but due to high computational demand, a single input deconvolution algorithm might be preferable in clinical practice. PMID: 31724443 [PubMed - in process]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
A busy day at UNISON’s LGBT+ conference saw delegates discuss a number of major issues. Mental health was high on the agenda, with Alan Williams for the union’s North West LGBT group saying that there was a “concerningly high rate of suicide attempts by LGBT+ members” and called for more training for reps on the issues. Hannah Stephenson urged delegates to return to their branches and ask their employers for mental ill health training, while a speaker from the North West talked of how “one person with the right information can make all the difference”. She said that research suggests tha...
Source: UNISON meat hygiene - Category: Food Science Authors: Tags: Article News LGBT Source Type: news
This study aims to investigate the prevalence of alcohol and drugs of abuse in Italian drivers involved in road traffic crashes between 2011 and 2018. Toxicological analyses were performed on the whole blood of 7593 injured drivers. Alcohol and illicit dru...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Emilio Rodríguez-Castro1,2, Manuel Rodríguez-Yáñez1,2, Susana Arias1,2, María Santamaría1,2, Iria López-Dequidt1,2, Ignacio López-Loureiro1, Manuel Rodríguez-Pérez1, Pablo Hervella1, Tomás Sobrino1, Francisco Campos1, José Castillo1* and Ramón Iglesias-Rey1* 1Clinical Neurosciences Research Laboratory, Department of Neurology, Clinical University Hospital, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain2Stroke Unit, Department of Neurology, Hospital Clínico Universitario, Santiago...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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