Evaluation of plasma levels of tissue factor and tissue factor pathway inhibitor in patients with psoriasis.
Conclusions: It appears that further studies are necessary to explain this problem, perhaps to include an evaluation of TF levels in psoriatic skin. PMID: 31616219 [PubMed]
Conclusion: Chinese women had a substantially lower risk of venous thromboembolism during pregnancy and the postpartum period compared to that of Caucasians. The occurrence of pregnancy-related venous thromboembolism was largely confined to the early pregnancy period, probably related to the adoption of thromboprophylaxis, a lower rate of Cesarean section, and early mobilization. PMID: 31730677 [PubMed]
Authors: Leal T, Costa D, Gonçalves R Abstract A 74 year-old male patient was admitted to the emergency department due to diarrhea of a one-month duration. The patient had 5 to 7 bowel movements/day of liquid stool, without blood or mucus. He had also undergone a percutaneous endoscopic gastrostomy (PEG) tube placement 10 weeks previously due to post-stroke dysphagia, with endoscopic confirmation of its correct positioning. A course of antibiotics had already been prescribed and there was no improvement of the symptoms. PMID: 31729231 [PubMed - as supplied by publisher]
CONCLUSIONS: Because of its pleiotropic roles in several reproductive events and its association with some life-threatening pathological conditions of pregnancy, bikunin may represent a non-invasive marker for improving follow-up and early diagnosis. Studies showing its usefulness as a drug for reducing the risk of preterm delivery and improving neonatal outcomes have yielded interesting results that deserve to be investigated through further research. PMID: 31728877 [PubMed - as supplied by publisher]
ConclusionsTaken together, these results illustrate a new model in which Purβ functions to regulate the glucagon/ADCY6/cAMP/PKA/CREB signaling pathway to help maintain glucose homeostasis.Graphical abstract
ConclusionsThe use of the tesaglitazar-[F7, P34]-NPY conjugate is a promising strategy to make use of the beneficial PPARα/γ effects in adipocytes while potentially omitting adverse-effects in other tissues.Graphical abstract
ConclusionThis research supports and extends the ethnomedicinal use of C. songarica as diuretic and hypotensive agent. The results showed that AS-CS from C. songarica could present compounds responsible for hypotensive and diuretic activities with no signs of toxicity, and these effects could involve nitric oxide pathway activated by muscarinic receptors or/and inhibition of angiotensin converting enzyme.Graphical abstract
Publication date: Available online 16 November 2019Source: Journal of EthnopharmacologyAuthor(s): Mallappa H. Shalavadi, V.M. Chandrashekhar, I.S. MuchchandiAbstractEthnopharmacological relevanceConvolvulus pluricaulis Choisy commonly known as Shankhapushpi, is traditionally prescribed for nerve debility, loss of memory, epilepsy and as nervine tonic. Plant also proved to have diverse pharmacological activity but the neuroprotection in ischemic stroke were not found.Aim of the studyTo investigate the effect of Convolvulus pluricaulis against bilateral common carotid artery (BCCA) occlusion induced cerebral ischemic reperfu...
Publication date: Available online 16 November 2019Source: Canadian Journal of CardiologyAuthor(s): Subodh Verma, Deepak L. Bhatt
Publication date: Available online 15 November 2019Source: Canadian Journal of CardiologyAuthor(s): Adam W. Powell, Clifford Chin, Tarek Alsaied, Harry B. Rossiter, Samuel Wittekind, Wayne A. Mays, Adam Lubert, Gruschen VeldtmanABSTRACTBackgroundExercise limitation is almost universal among Fontan patients. Identifying unique clinical features in the small fraction of Fontan patients with normal exercise capacity (high capacity Fontan, HCF) provides potential to inform clinical strategies for those with low exercise capacity (usual Fontan, UF).MethodsWe performed a retrospective chart review of all single ventricle patient...
Publication date: Available online 15 November 2019Source: Canadian Journal of CardiologyAuthor(s): Nicolette Stogios, Bhagwanpreet Kaur, Ella Huszti, Jessica Vasanthan, Robert P. NolanABSTRACTBackgroundBehavioural counselling via internet- or mobile-based digital platforms is recommended for hypertension, however outcome heterogeneity is problematic in trials of this digital intervention. Our objective was to assess how therapeutic outcome was optimized in digital trials for hypertension, according to key features of the intervention design and protocol.MethodsWe identified randomized controlled digital trials for systoli...