Force and Collective Epithelial Activities.

Force and Collective Epithelial Activities.
Adv Exp Med Biol. 2019;1146:31-44
Authors: Ferrari A, Giampietro C
Abstract
Cells apply forces to their surroundings to perform basic biological activities, including division, adhesion, and migration. Similarly, cell populations in epithelial tissues coordinate forces in physiological processes of morphogenesis and repair. These activities are highly regulated to yield the correct development and function of the body. The modification of this order is at the onset of pathological events and malfunctions. Mechanical forces and their translation into biological signals are the focus of an emerging field of research, shaping as a central discipline in the study of life and gathering knowledge at the interface of engineering, physics, biology and medicine. Novel engineering methods are needed to complement the classic instruments developed by molecular biology, physics and medicine. These should enable the measurement of forces at the cellular and multicellular level, and at a temporal and spatial resolution which is fully compatible with the ranges experienced by cells in vivo.
PMID: 31612452 [PubMed - in process]

Source: Advances in Experimental Medicine and Biology - October 17, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research