Plasma renin measurements are unrelated to mineralocorticoid replacement dose in patients with primary adrenal insufficiency.

CONCLUSIONS: The relationship between mineralocorticoid dose and PRC is complex and this may reflect variability in sampling with respect to posture, timing of last mineralocorticoid dose, adherence and concomitant medications. Our data suggests that mineralocorticoid titration should not primarily be based only on PRC normalization, but also on clinical parameters as BP and electrolyte concentration.
PMID: 31613957 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - October 15, 2019 Category: Endocrinology Authors: Pofi R, Prete A, Thornton-Jones V, Bryce J, Ali SR, Faisal Ahmed S, Balsamo A, Baronio F, Cannuccia A, Guven A, Guran T, Darendeliler F, Higham C, Bonfig W, de Vries L, Bachega TASS, Miranda MC, Mendonca BB, Iotova V, Korbonits M, Krone NP, Krone R, Lenzi Tags: J Clin Endocrinol Metab Source Type: research