Isolation and characterization of bioactive compounds with antibacterial, antioxidant and enzyme inhibitory activities from marine-derived rare actinobacteria, Nocardiopsis sp. SCA21

In conclusion, to best of our knowledge these findings are the first report of isolation of 4-bromophenol and Bis (2-ethylhexyl) phthalate from genus Nocardiopsis, thus suggesting that rare actinomycetes are promising source of therapeutically important bioactive metabolites.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research

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In conclusion, the present method demonstrated to be reliable and suitable for daptomycin TDM in clinical routine.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionP. karwinskii leaf extract inhibited reactive oxygen species and exerted an anti-inflammatory effect. Moreover, this extract did not induce gastric damage in the animals. The bioactivity of the species was found to support its traditional use in traditional medicine. This orchid could be used to treat inflammatory diseases without causing the side effects associated with Nonsteroidal anti-inflammatory drugs. It can also be employed to treat other pathological conditions associated with oxidative stress. The findings herein form the basis for the future discovery of natural products that may serve as safe alternat...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: Antioxidants that are not specifically targeted to mitochondria fail to accumulate in significant amounts in critical sites of mitochondrial ROS production and may eventually interfere with the ensuing physiological signaling. Mitochondria-targeted antioxidants are more effective, but are expected to interfere with the mitochondrial ROS-dependent physiologic signaling. AA promotes multiple beneficial effects in mitochondria. The complex regulation of vitamin C uptake in these organelles likely contributes to its versatile antioxidant response, thereby providing a central role to the vitamin for adequate contro...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
In this study, we aimed to synthesize curcumin quantum dots by using a combination of mechanical and ultrasonic milling techniques. Besides, the antimicrobial efficacy of the quantum dots was also tested on necrotizing fasciitis causing bacteria. Electron micrograph of curcumin quantum dots showed that the particles were irregular in shape, with an average size of 13.7 nm. Curcumin quantum dots possess a zeta potential of −13.3 mV based on zeta potential analysis. The antimicrobial activity was tested on 7 test bacteria. Curcumin quantum dots exhibited wide spectrum antibacterial activity, as the particles inhibi...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 25 January 2020Source: Meat ScienceAuthor(s): Tooraj Mehdizadeh, Hossein Tajik, Ali Mojaddar Langroodi, Rahim Molaei, Alireza MahmoudianAbstractThe aim of the current study was to investigate the effects of pomegranate peel extract (PPE) and chitosan-starch (CH-S) composite film incorporated with Thymus kotschyanus essential oil (TEO) on the shelf-life of beef during storage period of 21 days at 4 °C. The physico-mechanical parameters, the color and Fourier Transform Infrared spectra values of the films were determined. Changes in odor, color, pH, thiobarbituric value for lipid ox...
Source: Meat Science - Category: Food Science Source Type: research
Publication date: Available online 25 January 2020Source: Food ChemistryAuthor(s): Gonzalo Cebrero, Oscar Sanhueza, Matías Pezoa, María E. Báez, Jessica Martínez, Mauricio Báez, Edwar FuentesAbstractSome minor constituents of honey samples were determined through a fluorometric-chemical characterization method and related multifactorially with their antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa and with their geographical origin. Rotated principal component analysis identified five significant components in honey: three related to antibacterial activity a...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 25 January 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Sudheesh N, Roger Hewson, Babak Afrough, Kevin Bewley, Govindakarnavar ArunkumarAbstractKyasanur Forest disease virus (KFDV) and Alkhurma hemorrhagic fever virus (AHFV) are enveloped, positive-stranded RNA viruses of clinical importance with complex enzootic life cycles involving hematophagous ticks which feed on small and large mammals. Humans and monkeys are dead-end hosts for these viruses. Recent trends in epidemiological data suggest both virus incidences are steadily increasing and their geographical distribution expandi...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Authors: Habenstein B, El Mammeri N, Tolchard J, Lamon G, Tawani A, Berbon M, Loquet A Abstract Among the Gram-negative bacterial secretion systems, type III secretion systems (T3SS) possess a unique extracellular molecular apparatus called the needle. This macromolecular protein assembly is a nanometre-size filament formed by the helical arrangement of hundreds of copies of a single, small protein, which is highly conserved between T3SSs from animal to plant bacterial pathogens. The needle filament forms a hollow tube with a channel ~20 Å in diameter that serves as a conduit for proteins secreted...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Publication date: Available online 25 January 2020Source: Research in MicrobiologyAuthor(s): Priscila R. Guerra, Gang Liu, Sebastien Lemire, Arkadiusz Nawrockic, Egle Kudirkiene, Jakob Møller-Jensen, John E. Olsen, Lotte JelsbakAbstractPolyamines are small cationic amines required for modulating multiple cell process, including cell growth and DNA and RNA stability. In Salmonella polyamines are primarily synthesized from L-arginine or L-ornithine. Based on a previous study, which demonstrated that polyamines affect the expression of virulence gene in S. Typhimurium, we investigated the role of polyamines in the glob...
Source: Research in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 25 January 2020Source: Plant Physiology and BiochemistryAuthor(s): Hajar Ghafari, Hamid Hassanpour, Morad Jafari, Sina BesharatAbstractWater scarcity is one of the major factors limiting apple production. Partial root-zone drying (PRD) is a water-saving irrigation technique necessary to improve the efficiency of irrigation techniques to optimize the amount of fruit produced with the volume of water used. The apple trees cv. Red Delicious were exposed to four treatments, including (1) control with 100% of the crop evapotranspiration (ETc) needs; (2) alternate partial root-zone drying with ...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
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