IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis

Conclusions Theses results suggest that for individuals inheriting the IL6R C allele, the cytokine exerts a disease- and location-specific role in ALS. Follow-up, prospective studies are necessary, as this subgroup of patients may be identified as ideally responsive to IL6 receptor–blocking therapies.

http://nn.neurology.org/cgi/content/short/6/6/e631?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - October 13, 2019 Category: Neurology Authors: Wosiski-Kuhn, M., Robinson, M., Strupe, J., Arounleut, P., Martin, M., Caress, J., Cartwright, M., Bowser, R., Cudkowicz, M., Langefeld, C., Hawkins, G. A., Milligan, C. Tags: All Immunology, All Clinical Neurology, Amyotrophic lateral sclerosis, All Genetics Article Source Type: research