Protective effect of glycyrrhizic acid on cerebral ischemia/reperfusion injury via inhibiting HMGB1 ‐mediated TLR4/NF‐κB pathway

In this study, our results showed that GA could dramatically decrease cerebral edema, reduce the neurological deficits, and smaller brain infarct volume was found in the GA treatment group. In serum and brain tissue, GA also increased superoxide dismutase activity. In addition, in serum and brain tissue, GA also dramatically inhibited the secretion of inflammatory cytokines, including interleukin ‐1β (IL‐1β), IL‐6, and tumor necrosis factor‐α. Moreover, GA inhibited the expressions of high‐mobility group protein box‐1 (HMGB1)‐mediated TLR4/NF‐κB pathway. Our data determined that GA may provide protective effect on the I/R‐induced cerebral ischemia disease.
Source: Biotechnology and Applied Biochemistry - Category: Biochemistry Authors: Tags: Original Article Source Type: research