Peptides and peptidomimetics as inhibitors of protein-protein interactions involving β-sheet secondary structures.

Peptides and peptidomimetics as inhibitors of protein-protein interactions involving β-sheet secondary structures. Curr Opin Chem Biol. 2019 Oct 04;52:157-167 Authors: Laxio Arenas J, Kaffy J, Ongeri S Abstract Protein-protein interactions involving β-sheet secondary structures have been questioned in many fatal human diseases such as cancer, autoimmune and neurodegenerative diseases. Small selective peptide derivatives and analogues are promising drug candidates for inhibiting this poorly known class of PPIs. In this review, we will highlight the main strategies developed for designing linear and cyclic peptide and peptidomimetic inhibitors of PPIs involving β-sheet structures. These compounds either do not adopt preferred conformations or can mimic protein secondary structures such as β-strands, β-hairpins or α-helices. PMID: 31590141 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research