Proximal tubule ATR regulates DNA repair to prevent maladaptive renal injury responses

In conclusion, PT ATR activation is a key component of the DDR, which confers a protective effect mitigating the maladaptive repair and consequent fibrosis that follow kidney injury.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research

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AbstractCardiovascular disease (CVD) is a life-limiting comorbidity in patients with chronic kidney disease (CKD). In childhood, imaging studies have demonstrated early phenotypic characteristics including increases in left ventricular mass, carotid artery intima-media thickness, and pulse wave velocity, which occur even in young children with early stages of CKD. Vascular calcifications are the signature of an advanced phenotype and are mainly found in adolescents and young adults treated with dialysis. Association studies have provided valuable information regarding the significance of a multitude of risk factors in prom...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
AbstractBackgroundEnteral feeding by tube in chronic kidney disease (CKD) before 2 years of age improves growth. Whether it is effective after this age is unknown. We assessed whether height and weight SDS changed after tube feeding was started in children with CKD above 2 years of age.MethodsRetrospective study of pre-transplant, pre-pubertal children (
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionCommon Iliac Artery Aneurysms should be considered a differential diagnosis of lower abdominal mass. If presenting in this manner the aneurysm can be of significant size and at high risk of rupture, requiring urgent surgical intervention.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Rosa Anna Milella, Marica Gasparro, Fiammetta Alagna, Maria Francesca Cardone, Silvia Rotunno, Concetta Tiziana Ammollo, Fabrizio Semeraro, Apollonia Tullo, Flaviana Marzano, Domenico Catalano, Donato Antonacci, Mario Colucci, Domenica D'EliaAbstractUsing a transcriptomic approach, we performed a pilot study in healthy subjects to evaluate the changes in gene expression induced by grape consumption. Blood from twenty subjects was collected at baseline (T0), after 21 days of grape-rich diet (T1) and after one-month washout (...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Conditions:   Aortic Aneurysm, Abdominal;   Aortic Aneurysm, Thoracoabdominal;   Acute Renal Failure;   Acute Kidney Injury;   Acute Kidney Failure;   Acute Renal Insufficiency Intervention:   Device: Medyria TrackCath System Sponsors:   Medyria AG;   StatConsult Gesellschaft für klinische und Versorgungsforschung mbH;   Axxos GmbH;   Worldwide Clinical Trials;   Medical Mind RCS GmbH Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Prostate cancer (PC), which has high morbidity and mortality among elderly men, is becoming the most common malignancy in men. The progression of PC is associated with several aspects including apoptosis, proliferation and metastasis. C-Jun N-terminal kinase (JNK) is a member of mitogen-activated protein kinases (MAPKs), which play vital roles in regulating diverse cell processes. JNK has been shown to activate multiple substrates to modulate apoptosis, proliferation, tumorigenesis and inflammation in response to various stimuli including cytokines, pathogens, growth factors, oxidative stress, ultraviolet...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
As this article notes, researchers have recently suggested that the benefits to heart function observed over many years of stem cell therapies are not in fact due to any action of the cells themselves, not even cell signaling mechanisms such as release of exosomes, but are rather due to an immune response to the transplanted cells. The study reported here illustrates the point by showing some degree of regeneration of injured heart tissue to take place in mice when the debris of dead cells is transplanted. We might compare these findings with the body of work showing that delivery of exosomes can spur cardiac regeneration;...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(Baylor College of Medicine) A new mechanism that contributes to adult bone maintenance and repair opens the possibility of developing therapeutic strategies for improving bone healing.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This article explores five powerful ways that parents, caregivers and teachers can help young people discover the means to bounce themselves out of an automated self-scare routine and develop a personalised set of conscious self-care practices.  1. Get creative. Establishing habits is something that humans are very good at. Indeed, our lives can be conceptualised as the sum of the habits we have; these determine our actions as we move through the day, and in turn, how we make ourselves feel. The good news is that it only takes four weeks to establish a new habit, particularly with daily repetition. Guided to add ha...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: family featured health and fitness psychology self improvement kids mantra meditation Source Type: blogs
no Amelio The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview of the poten...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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