Increased cerebellar-default-mode network connectivity at rest in obsessive-compulsive disorder.

Increased cerebellar-default-mode network connectivity at rest in obsessive-compulsive disorder. Eur Arch Psychiatry Clin Neurosci. 2019 Sep 30;: Authors: Lv D, Ou Y, Chen Y, Yang R, Zhong Z, Jia C, Sun L, Wang Y, Zhang G, Sun Z, Wang W, Wang Y, Wang X, Guo W, Li P Abstract Abnormalities of the cerebellum and default-mode network (DMN) in patients with obsessive-compulsive disorder (OCD) have been widely reported. However, alterations of reciprocal functional connections between the cerebellum and DMN at rest in OCD remain unclear. Forty patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scan. Seed-based functional connectivity (FC) and support vector machine (SVM) were applied to analyze the imaging data. Compared with HCs, patients with OCD exhibited increased FCs between the left Crus I-left superior medial prefrontal cortex (MPFC) and between the right Crus I-left superior MPFC, left middle MPFC, and left middle temporal gyrus (MTG). A significantly negative correlation was observed between the right Crus I-left MTG connectivity and the Yale-Brown Obsessive-Compulsive Scale compulsion subscale scores in the OCD group (r = - 0.476, p = 0.002, Bonferroni corrected). SVM classification analysis indicated that a combination of the left Crus I-left superior MPFC connectivity and the right Crus I-left middle MPFC connectivity ca...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

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ConclusionThe current results suggest that aberrant functional interaction between the salience network (SN) and the DMN may represent a common substrate in the pathophysiology of OCD, while impaired functional coupling within the SN is distinct to autogenous-type OCD patients. These findings provide further neurobiological evidence to support the autogenous-reactive classification model and contribute to the understanding of the neurobiological basis for clinical heterogeneity in OCD.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: The remission of the patient suggested that CCT could be an alternative intervention for treatment-refractory OCD and those with severe OCD could be cured in short-term. PMID: 31756555 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Limbic cortico-striato-thalamo-cortical functional connectivity in drug-naïve patients of obsessive-compulsive disorder. Psychol Med. 2019 Oct 23;:1-13 Authors: Zhao Q, Xu T, Wang Y, Chen D, Liu Q, Yang Z, Wang Z Abstract BACKGROUND: The pathophysiology of obsessive-compulsive disorder (OCD) remains unclear despite extensive neuroimaging work on the disorder. Exposure to medication and comorbid mental disorders can confound the results of OCD studies. The goal of this study was to explore differences in brain functional connectivity (FC) within the cortico-striato-thalamo-cortical (CSTC) loop of ...
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Authors: Gupta A, Khanna S, Jain R Abstract The main objective of this study is to assess the effectiveness of deep brain stimulation (DBS) of the ventral striatum (VS) of the anterior limb of internal capsule for patients suffering from refractory obsessive-compulsive disorder (OCD) and to compare its result with traditional anterior capsulotomy. The present study consisted of two patients subjected to stimulation of ventral capsule (VC)/VS region of internal capsule for refractory OCD. Leads were implanted on both sides stereotactically using fused images of magnetic resonance imaging and computed tomography scan...
Source: Indian Journal of Psychiatry - Category: Psychiatry Tags: Indian J Psychiatry Source Type: research
ConclusionsThese results provide evidence that the impaired cognitive flexibility of OCD may be associated with dysfunctions of the brain network from the dorsal caudate (DC) to important nodes of the salience network. Our results extend the neuropsychological model of OCD by showing intrinsically different associations between OCD and HC in functional network and cognitive flexibility.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusions: This study found overlapping higher ReHo values in the right DLPFC of OCD patients and their unaffected siblings. Our results suggest that the higher ReHo in the right DLPFC may be a potential neuroimaging endophenotype, which may reflect an increased genetic risk of OCD.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, we used resting-state functional magnetic resonance imaging to scan 45 OCD patients and 43 well-matched healthy controls (HCs). Thalamic subregions were defined according to the Human Brainnetome Atlas. The fractional amplitude of low-frequency fluctuations (fALFF) and FC seeding-based connectivity were compared using a two-sample t-test. Correlations between abnormal FC and clinical symptoms were analyzed in OCD patients. Compared with HCs, increased fALFF was found in the bilateral thalamus, and increased FC was observed between the right posterior parietal thalamus (PPtha) and left middle occipital gyrus ...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Hui Xu1,2,3, Chenguang Guo1, Haining Li1, Lin Gao2, Ming Zhang1* and Yuan Wang1* 1Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China 2Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi'an Jiaotong University, Xi'an, China 3Faculty of Dentistry, University of Toronto, Toronto, ON, Canada Background and Purpose: Hemifacial spasm (HFS) is a rare neuromuscular disorder characterized by unilateral, involuntary, and paroxysmal contractions of orofacial muscles. To eluci...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In conclusion, our study demonstrates that TS patients manifest “trait” abnormalities in the timing of sequential motor tasks, which are in keeping with the continuation phase of time processing, likely controlled by the sensorimotor loop of the cortico-basal ganglia network. We also show that the abnormal lateralization of fine motor control, previously reported in the context of the structural sequencing of fine motor tasks, extends also to motor timing accuracy. Finally, we highlight SMA connectivity as a potentially pivotal neural substrate of adaptive compensation of motor timing deficits in fine manual ta...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Prefrontal gyrification is reduced in children with ADHD who also carry the DRD4 7R allele, and it relates to critical functional skills in the executive domain in carriers of the risk allele. More broadly, these effects highlight the importance of considering precise neurodevelopmental mechanisms through which risk alleles influence cortical neurogenesis and migration.IntroductionAttention deficit/hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder characterized by developmentally inappropriate symptoms of inattention, impulsivity, and hyperactivity. The disorder is thought to affect ar...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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