A compact system for intraoperative specimen imaging based on edge illumination X-ray phase contrast.

A compact system for intraoperative specimen imaging based on edge illumination X-ray phase contrast. Phys Med Biol. 2019 Sep 30;: Authors: Havariyoun G, Vittoria FA, Hagen CK, Basta D, Kallon GK, Endrizzi M, Massimi L, Munro PRT, Hawker S, Smit B, Astolfo A, Larkin O, Waltham RM, Shah Z, Duffy SW, Nelan R, Peel A, Suaris T, Jones LJ, Haig IG, Bate D, Olivo A Abstract A significant number of patients receiving breast-conserving surgery (BCS) for invasive carcinoma and ductal carcinoma in situ (DCIS) may need reoperation following tumor-positive margins from final histopathology tests. All current intraoperative margin assessment modalities have specific limitations. As a first step towards the development of a compact system for intraoperative specimen imaging based on edge illumination X-ray phase contrast, we prove that the system's dimensions can be reduced without affecting imaging performance. We analysed the variation in noise and contrast to noise ratio (CNR) with decreasing system length using the edge illumination X-ray phase contrast imaging setup. Two (planar) and three (computed tomography (CT)) dimensional imaging acquisitions of custom phantoms and a breast tissue specimen were made. Dedicated phase retrieval algorithms were used to separate refraction and absorption signals. A 'single-shot' retrieval method was also used, to retrieve thickness map images, due to its simple acquisition procedure and reduced acquisition ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research