1668OCRYODESMO-O1: A French nationwide phase II study on cryoablation in progressing desmoid tumour (DT) patients (pts)

ConclusionsThe study met is primary endpoint with 86% of non-progressive disease at  + 12 months, reduced pain and better functional status. CA in the hands of expert interventional radiologists, should be considered in guidelines as a reasonable treatment option for these pts. CA will soon challenge medical therapy as front-line therapy in the forthcoming randomized trial CRYO DESMO-02.Clinical trial identificationNCT02476305.Legal entity responsible for the studyH ôpitaux Universitaires de Strasbourg.FundingFrench National Cancer Institute (INCa).DisclosureJ. Kurtz: Travel / Accommodation / Expenses: PharmaMar; Travel / Accommodation / Expenses: Roche; Advisory / Consultancy, Travel / Accommodation / Expenses: Tesaro; Advisory / Consultancy, Travel / Accommodation / Expenses: AstraZeneca. X. Buy: Honoraria (self): Galil BTG. F. Deschamps: Honoraria (self): BTG; Honoraria (self): Medtronic; Honoraria (self): Covidien. A. gangi: Speaker Bureau / Expert testimony, Travel / Accommodation / Expenses: Canon medical; Licensing / Royalties: Apriomed; Non-remunerated activity/ies: BTG. All other authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research

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We report a case of a patient with advanced cervical cancer who presented with uncontrollable pain, MDD, and a suicide attempt. RESULT: A 39-year-old woman diagnosed with cervical cancer stage IVB presented to the Emergency Department after a suicide attempt by hanging. Upon evaluation by the palliative care psychiatrist, she reported intense pain, unresponsive to analgesics, and had a history of persistent suicidal ideation. Antidepressant treatment was started (sertraline 50mg/d) after a single dose of ketamine hydrochloride IV (0.5 mg/kg) was administered. Treatment response was measured using the Brief Edinburgh D...
Source: Palliative and Supportive Care - Category: Palliative Care Authors: Tags: Palliat Support Care Source Type: research
AbstractHigh dose of radiation to bone may cause necrosis. Osteoradionecrosis of the cervical vertebrae is a rare adverse event of radiotherapy in patients treated for head and neck cancer. The risk on osteoradionecrosis will increase with doses exceeding 60  Gy. Minimal trauma of the overlying mucosa of the heavily irradiated cervical spine causes subsequent infections or instability may cause neck pain and severe neurological disability. In four patients the cervical spine received up to 100 Gy due to reirradiation. Clinically the patients presented with neck pain. All patients had defects in the pharyngeal pos...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
This study is the culmination of a decade of research that has repeatedly demonstrated that this vaccine can effectively and safely target in animal models what we think may cause Alzheimer's disease. I believe we're getting close to testing this therapy in people." Although earlier research established that antibodies significantly reduce amyloid buildup in the brain, researchers needed to find a safe way to introduce them into the body. A vaccine developed elsewhere showed promise in the early 2000s, but when tested in humans, it caused brain swelling in some patients. The new idea was to start with DNA codin...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A young boy from the Philippines with leprosy. The chronic disease is curable, and if treated in time disabilities related to the disease can be averted. Courtesy: moyerphotos/CC By 2.0By Elisio MuchangaMAPUTO, Jul 30 2018 (IPS)In the first six months of this year, the southern African nation of Mozambique has already registered 300 more cases of leprosy, some 951 cases, than it registered for the whole of 2017.The country, which had previously eliminated the chronic disease in 2008, is receiving funding from the Nippon Foundation—a non-profit philanthropic organisation from Japan that is active in many countrie...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Development & Aid Featured Headlines Health Population Poverty & SDGs Regional Categories TerraViva United Nations Nippon Foundation Source Type: news
“A bear, however hard he tries, grows tubby without exercise.” – A. A. Milne You don’t need to knock yourself out at the gym each day to reap the many health benefits of daily exercise. With simple planning and a determination to engage in a healthier lifestyle, you can add easy stints of exercise to your schedule without breaking too much of a sweat. Best of all, you may realize some of these 10 health benefits of daily exercise. Exercise elevates your mood When you are physically active, it stimulates brain chemicals that make you feel better and lifts your mood. Some experts say that exercise of ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Habits Health-related LifeHelper Self-Help Source Type: blogs
CONCLUSION An isolated RAS mutation in invasive FVPTC may be associated with an aggressive clinical behavior.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
By Susan Blumenthal, M.D. and Alexandrea Adams The recent commemoration of National Women’s Health Week provided an important time to mark the progress that has been made in advancing women’s health over the past two decades and to highlight what more needs to be done to achieve women’s health equity in America. Historically, women have experienced discrimination in health care despite making 80 percent of health care decisions for their families, using more medical services than men, and suffering greater disability from chronic disease. Before the mid 1990’s, women were often excluded as subjects ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
ConclusionMusculoskeletal impairment is a significant side effect in head and neck cancer survivors that results in chronic neck pain, shoulder disability, trismus, and postural deficits. Tools to describe postural deficits are needed.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Percutaneous vertebroplasty (PVP) has been shown to release spinal pain and stabilize the vertebral body. PVP is suggested as an alternative treatment in spinal metastasis. Although cervical metastases is less prevalent than thoracic and lumbar spine, PVP procedure in cervical vertebrae remains technical challenging. We retrospectively analyzed the data from patients (n = 9) who underwent PVP using anterolateral approach to treat severe neck pain and restricted cervical mobility from metastatic disease. Patients were rated using modified Tokuhashi score and Tomita score before the procedure. Visual analog...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
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