Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study

Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM).
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Sara Jo Nixon, Ben LewisAbstractEpidemiological estimates indicate not only an increase in the proportion of older adults, but also an increase in those who continue moderate alcohol consumption. Substantial literatures have attempted to characterize health benefits/risks of moderate drinking lifestyles. Not uncommonly, reports address outcomes in a single outcome, such as cardiovascular function or cognitive decline, rather than providing a broader overview of systems. In this narrative review, retaining focus on neurobiological consi...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Authors: Takahashi T, Matsuura C, Toyoda K, Suzuki Y, Yamada N, Kobayashi A, Sugai S, Shimoi K Abstract In order to estimate the potential risk of chemicals including drug in patients with type 2 diabetes mellitus (T2DM), we investigated allyl alcohol induced liver injury using SD rats and Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats as a model for human T2DM. The diabetic state is one of the risk factors for chemically induced liver injury because of lower levels of glutathione for detoxification by conjugation with chemicals and environmental pollutants and their reactive metabolites. Allyl alcohol is met...
Source: Journal of Toxicological Sciences - Category: Toxicology Tags: J Toxicol Sci Source Type: research
AbstractNon-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2 diabetes. Although epidemiological studies have shown that NAFLD is associated with cardiovascular disease (CVD), it remains unknown whether NAFLD is an active contributor or an innocent bystander. Plasma lipids, low-grade inflammation, impaired fibrinolysis and hepatokines are potential mediators of the relationship between NAFLD and CVD. The Mendelian randomisation approach can help to make causal inferences. Studies that used common variants inPNPLA3,TM6SF2 andGCKR as instruments to investigate the relationship between NA...
Source: Diabetologia - Category: Endocrinology Source Type: research
Abstract Empagliflozin reduces blood glucose levels independently of insulin secretion by reducing glucose reabsorption in the proximal renal tubules through inhibition of sodium-glucose cotransporter 2 (SGLT2). Because SGLT2 inhibitors have a different mechanism of action to conventional antidiabetic drugs, recommendations have been issued about the management of specific side effect such as ketoacidosis, urinary tract infection, and genital infection. There have been some reports of SGLT2 inhibitor-associated euglycemic diabetic ketoacidosis (euDKA), but there have been few reports about euDKA in patients with t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease worldwide, affecting 25 –30% of the general population [1], with its prevalence reaching 55% in patients with type 2 diabetes mellitus (T2DM) [2] or even 90% in morbidly obese individuals [3]. NAFLD is characterized by fat accumulation in ≥5% of the hepatocytes, in the absence of excessive alcohol consumption or other secondary causes of liver diseases [4,5]. At the early stages of NAFLD, there is only liver steatosis (i.e.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
This article reviews the most updated information about NAFLD-related HCC and provides some insight into strategies that must be considered to reduce its potential disease burden.
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Publication date: Available online 5 November 2019Source: International Review of NeurobiologyAuthor(s): Sara Jo Nixon, Ben LewisAbstractEpidemiological estimates indicate not only an increase in the proportion of older adults, but also an increase in those who continue moderate alcohol consumption. Substantial literatures have attempted to characterize health benefits/risks of moderate drinking lifestyles. Not uncommonly, reports address outcomes in a single outcome, such as cardiovascular function or cognitive decline, rather than providing a broader overview of systems. In this narrative review, retaining focus on neuro...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are hepatic manifestations of metabolic syndrome and are increasing globally.1,2 Patients with NAFLD/NASH often present with either type 2 diabetes (T2D) or have insulin resistance and elevated fasting insulin levels, which are all established precursors for the development of diabetes and for adverse macrovascular sequalae.3 –5 NASH, T2D, and insulin resistance are thought to be growing in incidence and severity because of the increased availability of nutrients and consequent overnutrition.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Nearly half of all premature deaths may be due to unhealthy lifestyle choices, such as insufficient exercise, poor diet, and smoking. These risk factors increase the risk of high blood pressure, diabetes, heart attack, and stroke. The good news is that lifestyle changes can make a difference. In a study analyzing over 55,000 people, those with favorable lifestyle habits such as not smoking, not being obese, engaging in regular physical activity, and eating a healthy diet lowered their heart disease risk by nearly 50%. The American College of Cardiology (ACC) and the American Heart Association (AHA) recently published guide...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alcohol Diabetes Exercise and Fitness Heart Health Hypertension and Stroke Smoking cessation Source Type: blogs
Abstract AIMS: Recent epidemiological studies have suggested an association between sarcopenia and non-alcoholic fatty liver disease (NAFLD) in the general population, prompting our investigation into the gender-specific association between sarcopenia and NAFLD in patients with type 2 diabetes mellitus (T2DM). METHODS: In this cross-sectional study, 4210 patients with T2DM were recruited from the Seoul Metabolic Syndrome Cohort. Appendicular skeletal muscle mass (ASM) was estimated from bioimpedance analysis measurements, and the skeletal muscle mass index (SMI) was calculated by dividing the sum of ASM by bo...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
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