Chemoprevention of Colorectal Cancer

Although colorectal cancer (CRC) screening has reduced the incidence and mortality from CRC, chemoprevention strategies have potential to further reduce CRC incidence and mortality. Chemoprevention agents might be used for average-risk as well as high-risk groups, and to prevent colorectal cancer recurrence after therapy. CRC chemoprevention agents that have been studied include aspirin, non-aspirin non-steroidal anti-inflammatory drugs, statins, agents that target metabolic pathways, and vitamins and minerals.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research

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Novel pharmacological therapies are in development for cancer, ranging from conventional chemotherapeutic drugs to molecular targeted drugs, antibody-based drugs, and immune checkpoint inhibitors, which are developed using new technologies. However, the increasing cost of new drug development is increasing the costs of national healthcare and putting pressure on government finances worldwide. Under these circumstances, drug repositioning (i.e. discovering novel effects of existing drugs, thereby allowing their use to treat other diseases) has become a major focus because of reliability and cost reduction. It is becoming in...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Review Article: Lifestyle Source Type: research
(CNN) — Leading nutritional experts in the United States and the UK are fired up about new dietary recommendations claiming there’s no need to reduce your red and processed meat intake for good health. “This is a very irresponsible public health recommendation,” said Dr. Frank Hu, who chairs the nutrition department at the Harvard T.H. Chan School of Public Health. The new guidelines and five corresponding studies are part of a systematic analysis of existing research done by NutriRECS, a recently formed international group of nutritionists and health researchers. NutriRECS says its mission is to &l...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated CBSN Boston Syndicated Local CNN Red Meat Source Type: news
Publication date: Available online 18 September 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Shih-Wei Lai, Yu-Hung Kuo, Chia-Wei Fang, Kuan-Fu Liao
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Gastric cancer incidence and death half as likely over 22 years after short-term H. pylori treatment Related items fromOnMedica Antivirals cut liver cancer risk after hepatitis C Statins might not cut colorectal cancer risk after all Antibiotics, H2RAs and PPIs linked to child obesity Long-term use of PPIs linked to doubling in stomach cancer risk Taking aspirin with a PPI reduces risk of oesophageal cancer
Source: OnMedica Latest News - Category: UK Health Source Type: news
No abstract available
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: LETTERS TO THE EDITOR Source Type: research
Abstract The anticarcinogenic effect of statins may reduce the metastatic potential of cancer cells leading to 'stage migration', with users more likely diagnosed with early rather than late stage cancer. The association between prior statin use and colorectal cancer (CRC) stage at diagnosis in the Women's Health Initiative (WHI) was investigated. The study population included 132,322 post-menopausal women, among which there were 2,628 pathologically confirmed cases of in situ (3.3%), localized (43.6%), regional (40.4%) and distant (12.7%) stage CRC, after an average of 13.9 (SD=4.7) years of follow-up. To reduce ...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
But lower rectal cancer risk, suggesting differences in microbiome activity along the length of the bowel, say researchers Related items fromOnMedica Cetuximab with chemo shrinks more secondaries Statins might not cut colorectal cancer risk after all Invest in workforce to roll out bowel cancer screening, urges former health secretary Bowel cancer screening tests exceed target set in Scotland FOB associated with rise in all-cause mortality
Source: OnMedica Latest News - Category: UK Health Source Type: news
This review focuses on the role of oxidized sterols in three major gastrointestinal cancers (hepatocellular carcinoma, pancreatic and colon cancer) and how the circadian clock affects the carcinogenesis by regulating the lipid metabolism and beyond. While each field of research (cancer, oxysterols, and circadian clock) is well studied within their specialty, little is known about the intertwining mechanisms and how these influence the disease etiology in each cancer type. Oxysterols are involved in pathology of these cancers, but final conclusions about their protective or damaging effects are elusive, since the effect dep...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs
Conclusions: Our result suggests that, among CRC patients with MetS, taking metformin and statins may improve overall survival, whereas being on insulin may negatively impact CRC prognosis. Further studies are warranted to determine the exact mechanism through which metformin, statins, and insulin exert their effects on CRC survival. PMID: 31139216 [PubMed]
Source: Journal of Cancer Epidemiology - Category: Epidemiology Tags: J Cancer Epidemiol Source Type: research
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