Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model

High-dose fractionated proton therapy is used to manage patients with skull base tumors such as clival chordomas or chondrosarcomas [8,14]. Proton therapy is also used in the treatment of patients with lower grade gliomas [22], meningiomas, and subsets of head and neck cancer patients with particular dosimetric benefit, such as those with tumors of the paranasal sinuses [17]. Clinical outcomes support the utility of proton therapy in the disease control of these tumors but little is known on potential late side effects of brain radiation necrosis.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research