Volumetric and actuarial analysis of brain necrosis in proton therapy using a novel mixture cure model
High-dose fractionated proton therapy is used to manage patients with skull base tumors such as clival chordomas or chondrosarcomas [8,14]. Proton therapy is also used in the treatment of patients with lower grade gliomas [22], meningiomas, and subsets of head and neck cancer patients with particular dosimetric benefit, such as those with tumors of the paranasal sinuses [17]. Clinical outcomes support the utility of proton therapy in the disease control of these tumors but little is known on potential late side effects of brain radiation necrosis.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Maximilian Niyazi, Andrzej Niemierko, Harald Paganetti, Matthias S öhn, Emily Schapira, Saveli Goldberg, Judith Adams, Vince Kim, Kevin S. Oh, William L. Hwang, Hsiao-Ming Lu, Claus Belka, Paul M. Busse, Jay S. Loeffler, Helen A. Shih Tags: Original Article Source Type: research
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