HER2 Regulates Cancer Stem Cell Activities via the Wnt Signaling Pathway in Gastric Cancer Cells.

CONCLUSIONS: These results established a role for HER2 in regulating gastric CSC activity, with Wnt/β-catenin signaling being mediated via a HER2-dependent pathway. In summary, HER2-overexpressing gastric cancer cells exhibited increased stemness and invasiveness and were regulated by Wnt/β-catenin signaling.
PMID: 31550723 [PubMed - as supplied by publisher]

Source: Oncology - September 23, 2019 Category: Cancer & Oncology Authors: Jung DH, Bae YJ, Kim JH, Shin YK, Jeung HC Tags: Oncology Source Type: research