MRI Helps Us Distinguish Benign from Malignant Meningioma

Magnetic resonance imaging (MRI) could be a successful technology for understanding the severity ofmeningioma, according to a  studyrecently published inClinical Radiology. Determining if meningioma is high grade or low grade can help physicians decide how the tumor should be managed. Researchers from the American University Beirut Medical Center ventured to find out if MRI could help identify the meningioma grade before it ’s removed from the patient, making surgery easier and safer. The researchers analyzed scans of 71 patients who had undergone surgeries to remove intracranial meningiomas at American University between 2008 and 2017. They were able to compare features on both quantitative and qualitative MRI and CT scans as a way to categorize benign from malignantmeningiomas. They found that MRI “showed great promise” for identifying meningioma, scoring a specificity rate of 79 percent, negative predictive value of 92 percent, positive predictive value of seven percent and a sensitivity rate of 20 percent. Scan evaluations showed several MRI features were associated with high-grade meningiomas, among those features include: tumor size and volume, heterogenous enhancement, presence of intra-tumoral necrosis and brain invasion.   “The results of the present study showed that the most significant findings to differentiate between the two groups included a heterogeneous pattern of enhancement, as well as the presence of in...
Source: radRounds - Category: Radiology Authors: Source Type: blogs

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We report a case of DIG in a three-month-old boy who presented to our pediatric emergency department with decreased activity and excessive crying. This case report highlights the computed tomography (CT) and magnetic resonance imaging (MRI) findings of this rare tumor. Non-contrast CT scan findings in our case initially masqueraded as an extra-axial arachnoid cyst; however, the MRI findings after contrast agent administration were typical for the diagnosis of DIG. PMID: 31555425 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
ConclusionsPDB is often diagnosed through incidental findings in a regular blood chemistry panel, particularly ALK, or through imaging done for another reason. The planar radiograph gives the best clue to the presence of PDB. The MDCT is mandatory for better outcomes in treatment of osteosarcoma, whereas MRI is best for depicting local intracranial extension. PET identifies the region of a tumor through FDG increase. Lastly, biopsy is necessary for confirming the tumor.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Conclusion We ascribe the incorrect diagnosis to insufficient understanding on imaging manifestations of brain neoplasm as well as clinical features of parasitosis. Thus, we review the MRI, FDG-PET-CT, MRS and DTI data of this case according to the timeline, refer to relevant studies, and point out the pitfalls. With a long course of slowly progressing, this was a rare case of secondary glioblastoma with the absence of isocitrate dehydrogenase 1 (IDH1) gene mutation.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: The relatively successful local control of brain metastases in these patients indicates that long-term survival may be attainable via concomitant chemotherapy. PMID: 31456502 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
We present the case of a patient with vertebral dissemination from an intracranial GBM without intra-dural space invasion. The patient underwent a gross total tumor removal followed by radiation therapy (RT) with concomitant temozolomide chemotherapy (STUPP protocol).Following the appearance of back pain, patient underwent whole body computed tomography (CT) and spinal magnetic resonance imaging (MRI) scan.Spinal-MRI highlighted multiple vertebral lesions not infiltrating dura mater being confined to vertebral bodies. CT scan demonstrated the absence of other repetitive lesions in both thorax and abdomen. Histological exam...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
CONCLUSIONS: Review authors found a disappointing lack of evidence on the accuracy of imaging in people with a diagnosis of melanoma at different points on the clinical pathway. Studies were small and often reported data according to the number of lesions rather than the number of study participants. Imaging with ultrasound combined with FNAC before SLNB may identify around one-fifth of those with nodal disease, but confidence intervals are wide and further work is needed to establish cost-effectiveness. Much of the evidence for whole body imaging for primary staging or re-staging of disease is focused on PET-CT, and compa...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Conclusion: The geometric accuracy of the diagnostic MET-PET co-registered with stereotactic MR in LGP is acceptable on phantom-based study. However, the MET-PET images could the limitations in providing exact stereotactic information in clinical study. PMID: 31154754 [PubMed - as supplied by publisher]
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
Non –small-cell lung cancer (NSCLC) guidelines advise to screen stage III NSCLC patients for brain metastases (BMs), preferably by magnetic resonance imaging (MRI) or when contraindicated or not accessible a dedicated contrast enhanced–computed tomography (dCE-CT), which can be incorporated in the staging 18Fluodeoxoglucose–positron emission tomography (18FDG-PET-CE-CT). In daily practice, often a dCE-CT is performed instead of a MRI. The aim of the current study is to evaluate the additive value of MRI after dCE-CT, incorporated in the 18FDG-PET-CE-CT.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
492Purpose: To investigate the ability of potential imaging biomarkers to predict the response of bevacizumab (known as Avastin) combined with conventional therapy in newly diagnosed glioblastoma. Materials and Methods: Patients newly diagnosed with glioblastoma after surgery were enrolled to receive Avastin plus conventional concurrent radiotherapy and temozolomide. 18F-AlF-NOTA-PRGD2 positron emission tomography/computed tomography (18F-RGD PET/CT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) were performed at baseline, week 3, and week 10 for each patient. Molecular information was assessed in pati...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Brain Imaging Reloaded II Source Type: research
Conclusions: Irrespective of the analytical approach, [18F]FET-PET is a robust tool for detection of late PsP with only minor differences between different analytical approaches. However, methodological standardization and harmonization are needed to ensure comparability between different centers.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Brain Imaging Reloaded II Source Type: research
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