Prospective Phase 2 Study of Umbilical Cord Blood Transplantation in Adult Acute Leukemia and Myelodysplastic Syndrome

Hematopoietic stem cell transplantation from alternative donors is becoming an increasingly important option. Since HLA-mismatched umbilical cord blood transplantation (CBT) was introduced as a treatment option for adult hematological disease around 2000 [1,2], transplant outcomes with CBT have gradually improved [3]. However, because CB was assessed as an alternative donor source, second to unrelated volunteer donor in the earlier era, the patient's physical condition sometimes deteriorated with a prolonged donor search and the patient missed optimal transplant timing.

Source: Biology of Blood and Marrow Transplantation - September 19, 2019 Category: Hematology Authors: Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Akio Kohno, Yasushi Onishi, Noriko Fukuhara, Masanobu Kasai, Nobuharu Fujii, Hisayuki Yokoyama, Hiroatsu Iida, Nobuhiro Kanemura, Atsushi Fujieda, Hiroatsu Ago, Source Type: research