The effects of gasotransmitters inhibition on biochemical and haematological parameters, and oxidative stress in propofol-anaesthetized wistar male rats.

This study aimed to investigate the effects of propofol through evaluating it`s interaction with nitric oxide - NO, hydrogen sulfide - H2S and carbon monoxide - CO. Wistar male rats were divided in 4 groups: 1) bolus injection of propofol (1% 10 mg/ml, 100 mg/kg bw, i.p.); 2) N(ω)-nitro-L-arginine methyl ester - L-NAME (NO synthase inhibitor, 60 mg/kg bw, i.p.)+bolus injection of propofol (1% 10 mg/ml, 100 mg/kg bw, i.p.); 3) DL-propargylglycine - DL-PAG (H2S synthase inhibitor, 50 mg/kg bw, i.p.)+bolus injection of propofol (1% 10 mg/ml, 100 mg/kg bw, i.p.); 4) Zinc protoporphyrin IX - ZnPPIX (CO synthase inhibitor, 50 μmol/kg bw, i.p.)+bolus injection of propofol (1% 10 mg/ml, 100 mg/kg bw, i.p.). Increased levels of albumins, low density lipoproteins, alkaline phosphatase, amylase, high sensitivity Troponin T and fibrinogen were found in L-NAME+propofol group. Platelet crit, platelet count, total cholesterol, high density lipoproteins were elevated in ZnPPIX+propofol group. Hydrogen peroxide was increased in all groups treated with gasotransmitters inhibitors. Reduced glutathione was reduced in all groups, superoxide dismutase activity only in L-NAME+propofol. The effect of propofol on various biochemical, haematological and oxidative stress markers may be at least in part mediated through interaction with three estimated gasotransmitters. PMID: 31536393 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research